M. Zheng

Polydopamine Nanoparticles as Mimicking RPE Melanin for the Protection of Retinal Cells Against Blue Light-Induced Phototoxicity

This study uses polydopamine nanoparticles to mimic RPE melanin and protect retinal cells from blue light-induced phototoxicity in Nrf2-deficient mice.

A Transcriptomic Hourglass In Brown Algae

The paper investigates the presence of a molecular hourglass pattern in brown algae, finding it in developmentally complex species but not in simpler ones.

The first discovery of SFTSV in the Centre of Metropolitan Beijing, China

This study identifies SFTSV circulation in central Beijing by surveying ticks and hedgehogs, revealing high seroprevalence and RNA prevalence in urban areas.

Highly efficient in vivo mutagenesis method based on the endonuclease and exonuclease activity of Bacillus alcalophilus RecJ (BaRecJ)

This paper introduces a novel mutagenesis method using BaRecJ's endonuclease and exonuclease activities, showing broader mutation spectra and improved trait-associated gene identification in E. coli and S. cerevisiae.

Sound-seeking before and after hearing loss in mice

This study shows that mice with bilateral hearing loss lose their ability to perform a sound-seeking task, while those with unilateral loss recover using a different strategy.

De novo multi-mechanism antimicrobial peptide design via multimodal deep learning

This paper introduces M3-CAD, a deep learning pipeline for designing multi-mechanism antimicrobial peptides to combat multidrug-resistant organisms, showing effectiveness in a skin wound infection model.

An Efficient and Safe Trans-complementation System for MPXV Mimicking Authentic Viral Infection

This paper develops a safe trans-complementation system for MPXV that mimics authentic infection, enabling research in lower biosafety labs without live virus.

Sex chromosome dominance in a UV sexual system

This study investigates the genetic and molecular interactions between U and V sex chromosomes in the brown alga Ectocarpus across its life cycle, revealing developmental regulation and histone modifications in the diploid sporophyte stage.

In vitro antimicrobial mechanism of diacerein and potential to reverse MRSE resistance to β-lactams

This study investigates diacerein's antimicrobial mechanism against MRSE and shows it can reverse β-lactam resistance by affecting efflux systems and inducing cell lysis.

Metabolic interactions of a minimal bacterial consortium drive robust nitritation at acidic pH

This study identifies a minimal bacterial consortium that efficiently drives nitritation at acidic pH through metabolic interactions and stress adaptation mechanisms.

Natural killer cell regulation of breast cancer stem cells mediates metastatic dormancy.

This study identifies natural killer cell regulation of breast cancer stem cells as a key factor in metastatic dormancy using immunocompetent mouse models.

An RGB based deep neural network for high fidelity Fusarium head blight phenotyping in wheat

This paper introduces an RGB-based deep neural network for high-fidelity Fusarium head blight phenotyping in wheat, achieving accuracy comparable to human scoring and demonstrating strong generalizability across field conditions.

Synergistic efficacy of tigecycline combined with apramycin against tet(X)-harboring Acinetobacter spp.

This study evaluates the synergistic effect of tigecycline with apramycin and amikacin against tet(X)-harboring Acinetobacter spp., finding significant synergy with apramycin.

Isolation and nitrogen removal characteristics of a novel aerobic denitrifying strain Achromobacter xylosoxidans GR7397

This study isolates a novel aerobic denitrifying strain, Achromobacter xylosoxidans GR7397, and demonstrates its efficient nitrate removal capacity under optimized conditions.

Distinct Myeloid Derived Suppressor Cell Populations Promote Tumor Aggression in Glioblastoma

This study identifies two unique myeloid-derived suppressor cell populations in glioblastoma that promote tumor growth and immune evasion.

Expanding the diversity of Accumulibacter with a novel type and deciphering the transcriptional and morphological features among co-occurring strains

This paper discovers a new type of Accumulibacter (Type III) with unique functional features and investigates transcriptional and morphological differences among co-occurring strains in wastewater treatment systems.

Proliferative Exhausted CD8 T Cells Exacerbate Long-lasting Anti-tumor Effects in Human Papillomavirus Positive Head and Neck Squamous Cell Carcinoma

The paper identifies a proliferative exhausted CD8+ T cell cluster in HPV-positive HNSCC that correlates with better patient survival and suggests potential therapeutic implications.

Targeted Protein Degradation via Nanoparticles

This paper introduces a generic nanoparticle-based method for targeted protein degradation that avoids case-by-case design and enables degradation of both intracellular and extracellular targets.

Cuproptosis is correlated with clinical status, tumor immune microenvironment and immunotherapy in colorectal cancer: a multi-omic analysis

This study identifies 16 cuproptosis-related molecules and develops a scoring system to predict prognosis, tumor immune microenvironment, and immunotherapy response in colorectal cancer.

Allosteric Regulation of Aptamer Affinity through Mechano-Chemical Coupling

This paper introduces a method to modulate aptamer affinity using a molecular clamp that destabilizes secondary structure through mechanical tension, demonstrating up to 65-fold affinity changes without prior structural knowledge.

Mechanical Deformation Behaviors and Structural Properties of Ligated DNA Crystals

This study investigates the mechanical deformation and structural properties of ligated DNA crystals using simulations and experiments, revealing complex behaviors not predictable from individual components.

A Modular Chemoenzymatic Approach to C14-Functionalized Steroids

This paper develops a modular chemoenzymatic method to synthesize diverse C14-functionalized steroids using a novel CYP14A enzyme and its variants.

PanGu Drug Model: Learn a Molecule Like a Human

The paper introduces PanGu Drug Model, a deep learning architecture for drug discovery that achieves state-of-the-art results in molecule property prediction, generation, and optimization.

Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

Regional Cell Atlas of Human Intestine Shapes Distinct Immune Surveillance

The paper creates a regional cell atlas of human intestine using single-cell RNA sequencing and spatial transcriptomics, revealing how microenvironment shapes immune surveillance and disease susceptibility.

Comparative genomic and pan-genomic characteristion of Staphylococcus epidermidis from different sources unveils the molecular basis and potential biomarkers of pathogenic strains

This study sequenced and analyzed 11 ocular trauma-sourced S. epidermidis genomes, identifying 10 potential biomarkers and revealing pathogenic strains may be independent of biofilm formation.

Machine-Perception Nanosensor Platform to Detect Cancer Biomarkers

This paper develops a machine-perception nanosensor platform using optical arrays and machine learning to detect cancer biomarkers in biofluids, achieving high F1-scores in uterine lavage samples.

Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: the Multi-Targeting Drug DREAM Challenge

The paper reports on a DREAM Challenge to predict multi-target kinase inhibitors for RET-based tumors and Tauopathy, using neural network-based machine learning approaches.

Microparticle-based Biochemical Sensing Using Optical Coherence Tomography and Deep Learning

This paper develops a platform for remote biochemical monitoring using microparticle-based biosensors and OCT, enhanced by deep learning for 3D time series data analysis.

Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes