Author

D. Zamarin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 6 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 5 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:clustering· 2

Frequent Co-Authors

B. Weigelt· 3 shared J. S. Reis-Filho· 2 shared A. Boire· 1 shared A. C. Huang· 1 shared A. C. Weiner· 1 shared A. Cercek· 1 shared A. Da Cruz Paula· 1 shared A. Gazzo· 1 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersCancer Biology

B. Weigelt

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Author profile →

7 papers

Recent·Most cited

Interferon response and epigenetic modulation by SMARCA4 mutations drive ovarian tumor immunogenicity

M. N. Brodeur, H. Dopeso, Y. Zhu, A. L. F. Longhini, A. Gazzo, S. Sun, R. Koche, R. Qu, P.-J. Hamard, Y. Bykov, H. Green, K. B. Chiappinelli, M. A. Ozsoy, T. Basili, R. Gardner, , D. Zamarin

This study shows that SMARCA4 mutations in ovarian cancer increase immunogenicity through interferon response and epigenetic changes, enhancing T cell and NK cell activity in the tumor microenvironment.

bioRxiv · Aug 8, 2023 · PreprintCancer Biology

Cancer associated fibroblasts serve as an ovarian cancer stem cell niche through noncanonical Wnt5a signaling

Y. Fang, X. Xiao, J. Wang, S. Dasari, D. Pepin, K. Nephew, D. Zamarin, A. K. Mitra

This study shows that cancer-associated fibroblasts maintain ovarian cancer stem cells via noncanonical Wnt5a signaling, which contributes to chemoresistance and relapse.

bioRxiv · Feb 28, 2023Cancer Biology

Induction of a CD8 T cell intrinsic DNA damage and repair response is associated with clinical response to PD-1 blockade in uterine cancer.

Y. Muroyama, S. Manne, N. Wellhausen, D. A. Oldridge, A. R. Greenplate, L. Chilukuri, D. Mathew, C. Xu, R. S. Herati, S. L. Berger, A. C. Huang, C. H. June, D. Zamarin, C. F. Friedman, E. J. Wherry

The paper identifies a CD8 T cell intrinsic DNA damage response linked to clinical response to PD-1 blockade in uterine cancer using high-dimensional single-cell analysis.

bioRxiv · Apr 16, 2022 · PreprintImmunology

Genomic characterization of metastatic patterns from prospective clinical sequencing of 25,000 patients

B. Nguyen, C. Fong, A. Luthra, S. A. Smith, R. G. DiNatale, S. Nandakumar, H. Walch, W. K. Chatila, R. Madupuri, R. Kundra, C. M. Bielski, B. Mastrogiacomo, A. Boire, S. Chandarlapaty, K. Ganesh, , Varghes

The paper analyzes genomic data from 25,000 patients to identify associations between genomic alterations and metastatic patterns across 50 tumor types, finding chromosomal instability correlates with metastatic burden in some cancers.

bioRxiv · Jun 28, 2021Cancer Biology

Geometric Network Analysis Provides Prognostic Information in Patients with High Grade Serous Carcinoma of the Ovary Treated with Immune Checkpoint Inhibitors

R. Elkin, J. H. Oh, Y. L. Liu, P. Selenica, B. Weigelt, J. S. Reis-Filho, D. Zamarin, J. O. Deasy, L. Norton, A. J. Levine, A. R. Tannenbaum

This paper introduces a network curvature-based method to predict prognosis in high-grade serous ovarian cancer patients treated with immune checkpoint inhibitors using copy number alterations.

bioRxiv · Jun 10, 2021Cancer Biology

The impact of mutational processes on structural genomic plasticity in cancer cells

T. Funnell, C. H. O'Flanagan, M. J. Williams, A. McPherson, S. McKinney, F. Kabeer, H. Lee, T. Masud, P. Eirew, D. Yap, A. W. Zhang, J. L. P. Lim, B. Wang, J. Brimhall, J. Biele, , S. Aparicio

The paper analyzes structural genomic variations in cancer cells to understand how mutational processes influence cell-to-cell genomic diversity and tumor evolution.

bioRxiv · Jun 3, 2021 · PreprintCancer Biology

Immune-active microenvironment in small cell carcinoma of the ovary, hypercalcemic type: rationale for immune checkpoint blockade

P. Jelinic, J. Ricca, E. Van Oudenhove, N. Olvera, T. Merghoub, D. A. Levine, D. Zamarin

The paper reports immune responses in SCCOHT tumors, showing PD-L1 expression and T cell infiltration despite low mutation burden, suggesting potential for immune checkpoint blockade.

bioRxiv · Oct 4, 2017Cancer Biology