Author

D. F. J. Purcell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell-cell communication· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

G. Deliyannis· 2 shared L. J. M. Coin· 2 shared M. E. Pitt· 2 shared T. P. Stinear· 2 shared A. Takanashi· 1 shared B. Clemens· 1 shared B. Tran· 1 shared C. M. Weekley· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersImmunology

G. Deliyannis

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

mRNA vaccines encoding membrane-anchored receptor-binding domains of SARS-CoV-2 mutants induce strong humoral responses and can overcome immune imprinting

H. A. Al-Wassiti, S. A. Fabb, S. L. Grimley, R. Kochappan, J. K. Ho, C. Y. Wong, C. W. Tan, T. J. Payne, A. Takanashi, H. Sicilia, S. L. Y. Teo, J. L. McAuley, P. Ellenberg, J. P. Cooney, K. C. Davidson, , C. W. Pouton

bioRxiv · Oct 4, 2023Immunology

Uncovering strain- and age-dependent differences in innate immune response to SARS-CoV-2 infection in nasal epithelia using 10X single-cell sequencing

J. J.-Y. Chang, S. Grimley, B. Tran, G. Deliyannis, C. Tumpach, E. J. Steinig, S. L. Wong, S. A. Waters, T. P. Stinear, M. E. Pitt, D. F. J. Purcell, E. Vincan, L. J. M. Coin

The paper uses single-cell sequencing to compare innate immune responses to SARS-CoV-2 in nasal epithelial cells from adults and adolescents, finding age- and strain-dependent differences.

bioRxiv · Mar 4, 2023 · PreprintImmunology

SARS-CoV-2 Spike receptor-binding domain with a G485R mutation in complex with human ACE2

C. M. Weekley, D. F. J. Purcell, M. W. Parker

This study reports the crystal structure of SARS-CoV-2 Spike RBD with a G485R mutation bound to human ACE2, showing structural changes that may affect antigenic escape.

bioRxiv · Mar 16, 2021 · PreprintBiochemistry

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection

J. J.- Y. Chang, D. Rawlinson, M. E. Pitt, G. Taiaroa, J. Gleeson, C. Zhou, F. L. Mordant, R. De Paoli-Iseppi, L. Caly, D. F. J. Purcell, T. P. Stinear, S. L. Londrigan, M. B. Clark, D. A. Williamson, K. Subbarao, L. J. M. Coin

This study examines SARS-CoV-2 transcriptional and epi-transcriptional dynamics using long-read sequencing in human and primate infection models, revealing distinct patterns of sgRNA regulation and modification.

bioRxiv · Dec 22, 2020Microbiology

A Multiplex Droplet Digital PCR Assay for Quantification of HTLV-1c DNA Proviral Load and T-Cells from Blood and Respiratory Exudates Sampled in a Remote Setting

D. Yurick, G. Khoury, B. Clemens, L. Loh, H. Pham, K. Kedzierska, L. Einsiedel, D. F. J. Purcell

This study validates a duplex ddPCR assay to quantify HTLV-1c proviral load and T-cells in remote Indigenous Australian samples, comparing results to flow cytometry.

bioRxiv · Jul 8, 2018Microbiology