K. Subbarao

Parallel use of pluripotent human stem cell lung and heart models provide new insights for treatment of SARS-CoV-2

The paper uses human pluripotent stem cell-derived lung and heart models to identify antiviral compounds with distinct profiles, highlighting the need for multi-organ testing in SARS-CoV-2 treatment.

Robustness of the ferret model for influenza risk assessment studies: a cross-laboratory exercise

This study evaluates the consistency of ferret transmission experiments across laboratories for two H1N1 influenza viruses, finding concordant results and suggesting a minimum of three to five labs for reliable risk assessment.

Macrophages only sense infectious SARS-CoV-2 when they express sufficient ACE2 to permit viral entry, where rapid cytokine responses then limit viral replication.

The paper shows that ACE2-expressing macrophages allow SARS-CoV-2 entry and replication, triggering anti-viral responses, while ACE2-negative macrophages do not support viral entry or cytokine release.

Long-read RNA sequencing identifies polyadenylation elongation and differential transcript usage of host transcripts during SARS-CoV-2 in vitro infection

The paper uses long-read RNA sequencing to study polyadenylation and transcript usage changes in host cells during SARS-CoV-2 infection, identifying differential polyadenylation and transcript usage in infected cells.

An iTSC-derived placental model of SARS-CoV-2 infection unveils ACE2-dependent susceptibility in syncytiotrophoblasts

This study develops an in vitro model of SARS-CoV-2 infection in placental cells using iTSCs, showing that syncytiotrophoblasts are infected and that ACE2 inhibition prevents infection and restores function.

Enhanced metanephric specification to functional proximal tubule enables toxicity screening and infectious disease modelling in kidney organoids

This paper enhances kidney organoid maturation to produce functional proximal tubules, enabling better toxicity screening and infectious disease modeling.

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection

This study examines SARS-CoV-2 transcriptional and epi-transcriptional dynamics using long-read sequencing in human and primate infection models, revealing distinct patterns of sgRNA regulation and modification.

Prime-boost protein subunit vaccines against SARS-CoV-2 are highly immunogenic in mice and macaques

This study evaluates S and RBD subunit vaccines in mice and macaques, finding S is more immunogenic and boosting enhances neutralizing titers.

Bromodomain and Extraterminal Inhibition Blocks Inflammation-Induced Cardiac Dysfunction and SARS-CoV-2 Infection (Pre-Clinical)

The paper identifies BET inhibitors as potential cardio-protective drugs that block inflammation-induced cardiac dysfunction and SARS-CoV-2 infection in pre-clinical models.

Integrating genotypes and phenotypes improves long-term forecasts of seasonal influenza A/H3N2 evolution

This study develops a forecasting framework for influenza A/H3N2 evolution by integrating phenotypic antigenic drift data with sequence-based fitness estimates, showing improved long-term predictions.