Author

L. Caly

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:long-read sequencing· 2 Approach:statistical model· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

D. Rawlinson· 2 shared G. Taiaroa· 2 shared J. Druce· 2 shared A. J. McAuley· 1 shared C. Zhou· 1 shared D. A. Williamson· 1 shared D. F. J. Purcell· 1 shared D. Purcell· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersMicrobiology

D. Rawlinson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Highly Thermotolerant SARS-CoV-2 Vaccine Elicits Neutralising Antibodies Against Delta and Omicron in Mice

P. Jansen van Vuren, A. J. McAuley, M. J. Kuiper, N. B. Singanallur, M. P. Bruce, S. Riddell, S. Goldie, S. Mangalaganesh, S. Chahal, T. W. Drew, K. R. Blasdell, M. Tachedjian, L. Caly, J. D. Druce, S. Ahmed, , S. S. Vasan

This study evaluates a highly thermotolerant SARS-CoV-2 vaccine in mice, showing it elicits neutralizing antibodies against Delta and Omicron variants.

bioRxiv · Mar 3, 2022Immunology

Transcriptional and epi-transcriptional dynamics of SARS-CoV-2 during cellular infection

J. J.- Y. Chang, D. Rawlinson, M. E. Pitt, G. Taiaroa, J. Gleeson, C. Zhou, F. L. Mordant, R. De Paoli-Iseppi, L. Caly, D. F. J. Purcell, T. P. Stinear, S. L. Londrigan, M. B. Clark, D. A. Williamson, K. Subbarao, L. J. M. Coin

This study examines SARS-CoV-2 transcriptional and epi-transcriptional dynamics using long-read sequencing in human and primate infection models, revealing distinct patterns of sgRNA regulation and modification.

bioRxiv · Dec 22, 2020Microbiology

SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology

N. Ogando, T. Dalebout, J. C. Zevenhoven-Dobbe, R. W. A. L. Limpens, Y. van der Meer, L. Caly, J. Druce, J. de Vries, M. Kikkert, M. Barcena, I. Sidorov, E. J. Snijder

This study compares SARS-CoV-2 and SARS-CoV replication in Vero E6 cells, finding higher viral RNA levels in SARS-CoV-2 but lower infectious progeny, and adaptive mutations in its spike protein.

bioRxiv · Apr 20, 2020Microbiology

Direct RNA sequencing and early evolution of SARS-CoV-2

G. Taiaroa, D. Rawlinson, L. Featherstone, M. Pitt, L. Caly, J. Druce, D. Purcell, L. Harty, T. Tran, J. Roberts, N. Scott, M. Catton, D. Williamson, L. Coin, S. Duchene

The paper presents the first native RNA sequence of SARS-CoV-2, detailing its transcriptome and epitranscriptome, and infers genetic features and evolutionary rate.

bioRxiv · Mar 5, 2020 · PreprintMicrobiology