K. Kedzierska

Rapid recall and de novo T cell responses during SARS-CoV-2 breakthrough infection

This study examines T cell responses during SARS-CoV-2 breakthrough infections, showing rapid recall of memory T cells and a correlation between CD8+ T cell activation and viral clearance.

Type 17 Follicular Helper T (Tfh17) Cells are Superior for Memory Maintenance

This study shows that Tfh17 cells are more effective than Tfh1 and Tfh2 cells in maintaining memory responses after vaccination.

Single cell multi-omics reveals early elevated function and multiple fates within human progenitor exhausted CD8+ T cells

The paper identifies progenitor cells of T-cell exhaustion in acute HCV infection and shows their functional and phenotypic characteristics.

High expression of CD38 and MHC class II on CD8+ T cells during severe influenza disease reflects bystander activation and trogocytosis

This study investigates CD38 and MHC-II co-expression on CD8+ T cells during severe influenza, finding that it reflects bystander activation and trogocytosis from antigen-presenting cells, and is important for memory establishment.

SARS-CoV-2 mRNA vaccination elicits robust and persistent T follicular helper cell response in humans

This study shows that SARS-CoV-2 mRNA vaccination leads to strong and long-lasting T follicular helper cell responses in humans.

Dual TCR-alpha expression on MAIT cells as a potential confounder of TCR interpretation

The paper identifies dual TCR-alpha expression on MAIT cells as a confounder in TCR interpretation, showing non-TRAV1-2 TCRs do not bind MR1-5-OP-RU tetramer.

Atypical B cells are a normal component of immune responses to vaccination and infection in humans

This study identifies atypical B cells as a normal part of immune responses to vaccination and infection in humans, showing they are present in both malaria-exposed and healthy individuals.

Vaccine-specific immune responses against Mycobacterium ulcerans infection in a low-dose murine challenge model

This study evaluates a prime-boost vaccine against Mycobacterium ulcerans in mice, finding that both the experimental ER vaccine and BCG provide significant protection through distinct immune profiles.

A Multiplex Droplet Digital PCR Assay for Quantification of HTLV-1c DNA Proviral Load and T-Cells from Blood and Respiratory Exudates Sampled in a Remote Setting

This study validates a duplex ddPCR assay to quantify HTLV-1c proviral load and T-cells in remote Indigenous Australian samples, comparing results to flow cytometry.

MAIT cells contribute to protection against lethal influenza infection in vivo

This study shows MAIT cells protect against lethal influenza infection by accumulating and being activated early, with their absence increasing mortality in mice.