Structural basis for the unique multifaceted interaction of DPPA3 with the UHRF1 PHD finger
K. Hata, N. Kobayashi, K. Sugimura, W. Qin, D. Haxholli, Y. Chiba, S. Yoshimi, G. Hayashi, H. Onoda, T. Ikegami, C. B. Mulholland, A. Nishiyama, M. Nakanishi, H. Leonhardt, T. Konuma, K. Arita
This study determines the structure of the mouse UHRF1 PHD domain complexed with DPPA3, revealing how DPPA3 inhibits UHRF1 chromatin localization through unique interactions.
bioRxiv · Jun 14, 2022Biochemistry