Author

R. E. Randall

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:chicken / avian· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Vasou· 2 shared C. G. Bamford· 2 shared D. J. Hughes· 2 shared J. Andrejeva· 2 shared J. McLauchlan· 2 shared A. Filipe· 1 shared A. Hardy· 1 shared A. Shaw· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

A. Vasou

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Timing and magnitude of the type-I interferon response are determinants of disease tolerance in arbovirus infection

A. Hardy, S. Bakshi, W. Furnon, O. MacLean, Q. Gu, M. Varjak, M. Varela, M. A. Aziz, A. Shaw, R. M. Pinto, N. C. Ruiz, C. Mullan, A. Taggart, A. Filipe, R. E. Randall, , M. Palmarini

This study shows that the timing and magnitude of the type-I interferon response determine disease tolerance in bluetongue virus infection between sheep and cattle.

bioRxiv · Oct 19, 2022 · PreprintMicrobiology

A co-opted ISG15-USP18 binding mechanism normally reserved for deISGylation controls type I IFN signalling

A. Vasou, K. Nightingale, V. Cetkovska, J. Scheler, C. G. Bamford, J. Andrejeva, U. Schwarz-Linek, R. E. Randall, J. McLauchlan, M. P. Weekes, D. Bogunovic, D. J. Hughes

The paper identifies a new function of ISG15 in stabilizing USP18 through non-covalent interactions, revealing a mechanism that controls type I IFN signalling.

bioRxiv · Jun 1, 2021 · PreprintImmunology

Direct antiviral activity of interferon stimulated genes is responsible for resistance to paramyxoviruses in ISG15-deficient cells

D. Holthaus, A. Vasou, C. G. Bamford, J. Andrejeva, C. Paulus, R. E. Randall, J. McLauchlan, D. J. Hughes

The paper shows that ISG15-deficient cells are resistant to paramyxovirus infection due to direct antiviral activity of ISGs, but prolonged IFN treatment causes resistance through translational inhibition.

bioRxiv · Dec 12, 2019Immunology