Author

D. I. Mackie

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Pharmacology & Toxicology· 1

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Research Focus:cell signaling & trafficking· 1 Research Focus:development & morphogenesis· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

A. Inoue· 1 shared B. Al-Zaid· 1 shared D. R. Poyner· 1 shared D. Safitri· 1 shared D. Wootten· 1 shared G. Ladds· 1 shared H. Y. Yeung· 1 shared J. B. Pawlak· 1 shared

Activity by Year

2021-2021 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. Inoue

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1 paper

Recent·Most cited

RAMPs regulate signalling bias and internalisation of the GIPR

M. Harris, D. I. Mackie, J. B. Pawlak, S. Carvalho, T. T. truong, D. Safitri, H. Y. Yeung, S. Routledge, M. T. Harper, B. Al-Zaid, M. Soave, S. Al-Sabah, A. Inoue, D. R. Poyner, S. J. Hill, , G. Ladds

This study shows RAMPs modulate GIPR signaling and internalization, with RAMP3 reducing cAMP production and promoting surface retention, while RAMP1/2 decrease Gq/11/15 activation, and RAMP1 is essential for normal glucose regulation.

bioRxiv · Apr 8, 2021 · PreprintPharmacology & Toxicology