Author

M. T. Harper

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Organism:Drosophila· 1 Assay:electrophysiology· 1

Frequent Co-Authors

G. Ladds· 2 shared A. Chandran· 1 shared A. Inoue· 1 shared B. Al-Zaid· 1 shared D. C. Bulmer· 1 shared D. I. Mackie· 1 shared D. R. Poyner· 1 shared D. Safitri· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersPharmacology & Toxicology

G. Ladds

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

TRPV4 stimulates colonic afferents through mucosal release of ATP and glutamate

M. Y. Meng, L. W. Paine, D. Sagnat, I. Bello, S. Oldroyd, F. Javid, M. T. Harper, J. R. Hockley, E. S. J. Smith, R. M. Owens, L. Alric, E. Buscail, F. Welsh, N. Vergnolle, D. C. Bulmer

This study shows TRPV4 activation in the colon increases afferent activity via mucosal release of ATP and glutamate, suggesting a target for visceral pain treatment.

bioRxiv · Apr 12, 2024Pharmacology & Toxicology

RAMPs regulate signalling bias and internalisation of the GIPR

M. Harris, D. I. Mackie, J. B. Pawlak, S. Carvalho, T. T. truong, D. Safitri, H. Y. Yeung, S. Routledge, M. T. Harper, B. Al-Zaid, M. Soave, S. Al-Sabah, A. Inoue, D. R. Poyner, S. J. Hill, , G. Ladds

This study shows RAMPs modulate GIPR signaling and internalization, with RAMP3 reducing cAMP production and promoting surface retention, while RAMP1/2 decrease Gq/11/15 activation, and RAMP1 is essential for normal glucose regulation.

bioRxiv · Apr 8, 2021 · PreprintPharmacology & Toxicology

Proposed model of the Dictyostelium cAMP receptors bound to cAMP

J. C. Greenhalgh, A. Chandran, M. T. Harper, G. Ladds, T. Rahman

The paper presents homology models of cAMP receptors from Dictyostelium discoideum, highlighting structural features that may explain differential cAMP binding affinities and activation mechanisms.

bioRxiv · Jan 3, 2020Biochemistry