Author

D. J. Beebe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Bioengineering· 3 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Organism:human· 6 Research Focus:cell type annotation· 5 Research Focus:cell-cell communication· 4 Assay:bulk RNA-seq· 3 Research Focus:host-pathogen & immune response· 3 Assay:imaging· 3 Organism:bacteria (other)· 2

Frequent Co-Authors

A. Hurley· 2 shared A. Huttenlocher· 2 shared C. Li· 2 shared J. Handelsman· 2 shared J. Yu· 2 shared M. Humayun· 2 shared O. S. Venturelli· 2 shared S. C. Kerr· 2 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

A. Hurley

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Surface colonization by Flavobacterium johnsoniae promotes its survival in a model microbial community

S. Magesh, A. Hurley, J. Nepper, M. Chevrette, J. H. Schrope, C. Li, D. J. Beebe, J. Handelsman

This study identifies genes in Flavobacterium johnsoniae critical for surface colonization in both solitary and community settings using a model microbial community.

bioRxiv · Jan 5, 2024Microbiology

Neutrophil motility is regulated by both cell intrinsic and endothelial cell ARPC1B

A. N. Peterson, D. Bennin, M. Lasarev, J. Chini, D. J. Beebe, A. Huttenlocher

This study shows that ARPC1B in both neutrophils and endothelial cells regulates neutrophil motility, with endothelial ARPC1B being sufficient to drive neutrophil behavior.

bioRxiv · Nov 16, 2023Cell Biology

Modeling Sepsis-Associated ARDS Using a Lung Endothelial Microphysiological System

N.-W. Liang, C. Wilson, B. C. Davis, I. Wolf, T. Qyli, J. Moy, L. M. Schnapp, D. J. Beebe, S. C. Kerr, H. E. Faust

The paper uses a lung endothelial microphysiological system to study how sepsis plasma affects endothelial function, finding increased permeability and inflammatory markers.

bioRxiv · Oct 10, 2023 · PreprintCell Biology

Immune Cells and Inflammatory mediators cause endothelial dysfunction in a vascular microphysiological system

A. Rengarajan, H. E. Goldblatt, D. J. Beebe, M. Virumbrales-Munoz, D. S. Boeldt

This study uses a vascular microphysiological system to show that inflammatory mediators and activated PBMCs disrupt endothelial function by increasing permeability and reducing Ca2+ signaling.

bioRxiv · Sep 27, 2023Bioengineering

Naive primary neutrophils play a dual role in the tumor microenvironment

K. A. Babatunde, R. Datta, N. W. Hendikse, J. M. Ayuso, A. Huttenlocher, M. C. Skala, D. J. Beebe, S. C. Kerr

This study investigates the dual role of naive primary neutrophils in the tumor microenvironment, showing they both restrict tumor invasion and hinder NK cell penetration through ROS and NETs.

bioRxiv · Sep 15, 2023Cell Biology

Microbial Community Interactions on a Chip

D. S. Juang, W. E. Wightman, G. L. Lozano, L. J. Barkal, J. Yu, M. F. Garavito, A. Hurley, O. S. Venturelli, J. Handelsman, D. J. Beebe

The paper introduces a Microbial Community Interaction device to systematically study chemical and biological interactions in microbial communities, revealing antagonistic effects of gentamicin and vancomycin and community-level growth impacts.

bioRxiv · Oct 17, 2022Microbiology

Under-Oil Autonomously Regulated Oxygen Microenvironments: A Goldilocks Principle-Based Approach For Microscale Cell Culture

C. Li, M. Humayun, G. M. Walker, K. Y. Park, B. Connors, J. Feng, M. C. Pellitteri Hahn, C. O. Scarlett, J. Li, Y. Feng, R. L. Clark, H. Hefti, J. Schrope, O. S. Venturelli, D. J. Beebe

This paper introduces a method to create autonomously regulated oxygen microenvironments in microscale cell cultures using an oil overlay, validated with simulations and experiments across multiple cell types.

Advanced Science · Feb 4, 2022Peer-reviewedBioengineering

Transendothelial migration induces differential migration dynamics of leukocytes in tissue matrix

A. C. I. van Steen, L. Kempers, R. Schoppmeyer, M. Blokker, D. J. Beebe, M. A. Nolte, J. D. van Buul

This study uses a blood-vessel-on-a-chip model to analyze how T-cells and neutrophils migrate differently in a tissue matrix after transendothelial migration.

bioRxiv · Sep 2, 2021Cell Biology

Autofluorescence imaging of 3D tumor-macrophage microscale cultures resolves spatial and temporal dynamics of macrophage metabolism

T. Heaster, M. Humayun, J. Yu, D. J. Beebe, M. Skala

This paper uses autofluorescence imaging to study macrophage metabolism and behavior in 3D tumor models, revealing metabolic heterogeneity and migration patterns.

bioRxiv · Mar 12, 2020Bioengineering