Author

J. D. van Buul

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 6 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 6 Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Assay:imaging· 3 Research Focus:cell-cell communication· 2 Research Focus:development & morphogenesis· 2 Research Focus:differential expression· 2

Frequent Co-Authors

J. Goedhart· 5 shared J. J. G. Arts· 5 shared E. K. Mahlandt· 4 shared A. C. I. van Steen· 3 shared M. A. Nolte· 3 shared S. Tol· 3 shared F. H. van der Linden· 2 shared L. Kempers· 2 shared

Activity by Year

2019-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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5 shared papersCell Biology

J. Goedhart

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Opto-RhoGEFs: an optimized optogenetic toolbox to reversibly control Rho GTPase activity on a global to subcellular scale, enabling precise control over vascular endothelial barrier strength

E. K. Mahlandt, S. Palacios Martinez, J. J. G. Arts, S. Tol, J. D. van Buul, J. Goedhart

This paper develops Opto-RhoGEFs, an optogenetic tool to control Rho GTPase activity in endothelial cells, revealing a VE-cadherin-independent mechanism for regulating vascular barrier strength.

bioRxiv · Oct 17, 2022Cell Biology

Endothelial transmigration hotspots limit vascular leakage through heterogeneous expression of ICAM1

M. L. B. Grönloh, J. J. G. Arts, S. Palacios Martinez, A. A. van der Veen, L. Kempers, A. C. I. van Steen, J. J. T. H. Roelofs, M. A. Nolte, J. Goedhart, J. D. van Buul

The paper identifies endothelial transmigration hotspots that limit vascular leakage by heterogeneous ICAM-1 expression, showing that ICAM-1 distribution determines hotspot location and function.

bioRxiv · Jan 14, 2022 · PreprintImmunology

Transendothelial migration induces differential migration dynamics of leukocytes in tissue matrix

A. C. I. van Steen, L. Kempers, R. Schoppmeyer, M. Blokker, D. J. Beebe, M. A. Nolte, J. D. van Buul

This study uses a blood-vessel-on-a-chip model to analyze how T-cells and neutrophils migrate differently in a tissue matrix after transendothelial migration.

bioRxiv · Sep 2, 2021Cell Biology

A turquoise fluorescence lifetime-based biosensor for quantitative imaging of intracellular calcium

F. H. van der Linden, E. K. Mahlandt, J. J. G. Arts, J. Beumer, J. Puschhof, S. M. A. de Man, A. O. Chertkova, B. Ponsioen, H. Clevers, J. D. van Buul, M. Postma, T. W. J. Gadella, J. Goedhart

This paper introduces a new calcium biosensor based on fluorescence lifetime imaging, which provides accurate and pH-insensitive quantification of intracellular calcium concentrations.

bioRxiv · Jun 21, 2021Cell Biology

Visualizing endogenous RhoA activity with an improved localization-based, genetically encoded biosensor

E. K. Mahlandt, J. J. G. Arts, W. J. van der Meer, F. H. van der Linden, S. Tol, J. D. van Buul, T. W. J. Gadella, J. Goedhart

The paper improves RhoA localization-based biosensors to better detect endogenous RhoA activity in various cellular processes.

bioRxiv · Feb 8, 2021Cell Biology

Endothelial junctional membrane protrusions serve as hotspots for neutrophil transmigration

J. J. G. Arts, E. K. Mahlandt, M. Grönloh, L. Schimmel, I. Noordstra, A. C. I. van Steen, S. Tol, J. van Rijssel, M. A. Nolte, M. Postma, S. Khuon, J. M. Heddleston, E. Wait, T. L. Chew, M. Winter, , J. D. van Buul

The paper identifies endothelial junctional membrane protrusions as preferred sites for neutrophil transmigration during inflammation and shows they depend on Rac1 activity.

bioRxiv · Jan 18, 2021Cell Biology

DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis

M. van der Stoel, L. Schimmel, K. Nawaz, A.-M. van Stalborch, A. de Haan, A. Klaus-Bergmann, E. T. Valent, D. S. Koenis, G. P. van Nieuw Amerongen, C. J. de Vries, V. de Waard, M. Gloerich, J. D. van Buul, S. Huveneers

This study identifies DLC1 as a direct target of YAP/TAZ that regulates endothelial dynamics and sprouting angiogenesis.

bioRxiv · Sep 2, 2019Cell Biology