Author

D. J. DeGraff

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Organism:mouse· 2 Assay:proteomics· 2 Approach:statistical model· 2

Frequent Co-Authors

J. I. Warrick· 3 shared H. Yamashita· 2 shared V. Walter· 2 shared C.-W. Chen· 1 shared E. Giddings· 1 shared E. S. Dahl· 1 shared G. B. Mills· 1 shared G. P. Robertson· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

J. I. Warrick

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Author profile →

5 papers

Recent·Most cited

Urothelium-specific expression of mutationally activated Pik3ca initiates early lesions of non-invasive bladder cancer

L. Shuman, J. Pham, T. Wildermuth, X.-R. Wu, V. Walter, J. I. Warrick, D. J. DeGraff

This study creates a mouse model to study PIK3CA mutations in bladder cancer, showing early tumorigenic changes but no progression to invasion without additional genetic factors.

bioRxiv · May 22, 2023 · PreprintCancer Biology

Intratumoral Heterogeneity Promotes Collective Cancer Invasion Through NOTCH1 Variation

P. Torab, Y. Yan, M. Ahmed, H. Yamashita, J. Warrick, J. Raman, D. J. DeGraff, P. Wong

The paper shows that NOTCH1 variation within microtumors enhances invasiveness, linking intratumoral heterogeneity to collective cancer invasion.

Cells · Nov 9, 2021Peer-reviewedCancer Biology

AUTS2 controls neuronal lineage choice through a novel PRC1-independent complex and BMP inhibition

Z. Geng, Q. Wang, W. Miao, T. Wolf, J. Chavez, E. Giddings, R. Hobbs, D. J. DeGraff, Y. Wang, J. Stafford, Z. Gao

This study identifies a novel AUTS2-containing complex that inhibits BMP signaling to promote neuronal differentiation and reveals its role in neuronal lineage specification.

bioRxiv · Jun 29, 2021Biochemistry

Loss of the Pioneer Factor FOXA1 Results in Genome-wide Epigenetic Reprogramming and activation of Interferon-Response Genes including CD274/PD-L1

W. Hu, H. Yamashita, J. Craig, V. Walter, J. I. Warrick, H. Al-Ahmadie, D. J. DeGraff

This study shows that FOXA1 loss in bladder cancer causes widespread epigenetic changes and activates interferon-response genes like PD-L1.

bioRxiv · Sep 11, 2020 · PreprintCancer Biology

Suppression of p16 increases nucleotide synthesis via mTORC1

R. Buj, C.-W. Chen, E. S. Dahl, K. E. Leon, R. Kuskovsky, N. Maglakelidze, M. Navaratnarajah, G. Zhang, M. T. Doan, H. Jiang, M. Zaleski, L. Kutzler, H. Lacko, Y. Lu, G. B. Mills, , K. M. Aird

This study shows that p16 suppression increases nucleotide synthesis through mTORC1 activation, promoting tumorigenesis by bypassing senescence.

bioRxiv · Jul 20, 2019Cancer Biology