Author

Z. Geng

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Plant Biology· 2 Animal Behavior & Cognition· 1 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

Q. Wang· 2 shared S. Xu· 2 shared W. R. Liu· 2 shared Y. Liu· 2 shared Y. Wang· 2 shared Z. Gao· 2 shared A. Fahey· 1 shared B. Neuman· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBiochemistry

Q. Wang

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Data-driven optimization yielded a highly-efficient CRISPR/Cas9 system for gene editing in Arabidopsis

H. Geng, Y. Wang, Y. Xu, Y. Zhang, E. Han, Y. Peng, Z. Geng, Y. Liu, Y. Qin, S. Ma

The paper develops a CRISPR/Cas9 system for Arabidopsis using the NUC1 promoter, achieving high editing efficiency and stable inheritance in the T2 generation.

bioRxiv · Oct 9, 2023 · PreprintPlant Biology

An Azapeptide Platform in Conjunction with Covalent Warheads to Uncover High-Potency Inhibitors for SARS-CoV-2 Main Protease

K. Khatua, Y. R. Alugubelli, K. Yang, V. Reddy, L. Blankenship, D. Coleman, S. Atla, S. Chaki, Z. Geng, X. Ma, J. Xiao, P.-H. Chen, C.-C. Cho, E. C. Vatansever, Y. Ma, , W. R. Liu

This study develops an azapeptide platform with covalent warheads to identify potent SARS-CoV-2 MPro inhibitors, including MPI89 with a 10 nM EC50 and high selectivity.

bioRxiv · Apr 11, 2023 · PreprintBiochemistry

A Recurring Chemogenetic Switch for Chimeric Antigen Receptor T Cells

W. Cao, Z. Geng, N. Wang, Q. Pan, S. Guo, S. Xu, J. Zhou, W. R. Liu

This paper introduces a chemogenetic switch for CAR-T cells using HCV-NS3 protease, enabling controlled activation through ASV concentration modulation.

bioRxiv · Aug 23, 2021Bioengineering

AUTS2 controls neuronal lineage choice through a novel PRC1-independent complex and BMP inhibition

Z. Geng, Q. Wang, W. Miao, T. Wolf, J. Chavez, E. Giddings, R. Hobbs, D. J. DeGraff, Y. Wang, J. Stafford, Z. Gao

This study identifies a novel AUTS2-containing complex that inhibits BMP signaling to promote neuronal differentiation and reveals its role in neuronal lineage specification.

bioRxiv · Jun 29, 2021Biochemistry

Biochar effect - mediated ammonium transporter genes and GDH may be the core of improvement nitrogen assimilation in cotton seedling

L. Feng, G. Tang, W. Xu, M. Gu, Z. Geng

The paper investigates how biochar affects nitrogen assimilation in cotton seedlings by analyzing gene expression and enzyme activity under different urea and biochar conditions.

bioRxiv · Feb 22, 2020 · PreprintPlant Biology

Mutant p53 Drives Clonal Hematopoiesis through Modulating Epigenetic Pathway

S. Chen, Q. Wang, H. Yu, M. L. Capitano, S. Vemula, S. C. Nabinger, R. Gao, C. Yao, M. Kobayashi, Z. Geng, A. Fahey, D. Henley, S. Z. Liu, E. R. Wolf, B. Ramdas, , Y. Liu

This study identifies mutant p53's role in promoting clonal hematopoiesis by modulating the EZH2-mediated epigenetic pathway.

bioRxiv · Apr 24, 2019Cancer Biology

Hypothalamic transcriptome analysis reveals the neuroendocrine mechanisms in controlling broodiness of Muscovy duck (Cairina moschata)

P. Ye, M. Li, W. Liao, K. Ge, S. Jin, C. Zhang, X. Chen, Z. Geng, Min Li, Wang Liao, Kai Ge, Sihua Jin, Cheng Zhang, Xingyong Chen?Zhaoyu Geng, Pengfei Ye

The paper analyzes the hypothalamic transcriptome of Muscovy ducks across reproductive stages to identify gene expression changes and pathways involved in broodiness.

bioRxiv · Oct 25, 2018Animal Behavior & Cognition