E. S. Dahl

αKG-mediated carnitine synthesis promotes homologous recombination via histone acetylation

This study shows that αKG-mediated carnitine synthesis supports HR proficiency by promoting histone acetylation, which enhances DNA repair.

DOT1L modulates the senescence-associated secretory phenotype through epigenetic regulation of IL1A

This study shows that DOT1L regulates the senescence-associated secretory phenotype (SASP) through epigenetic control of IL1A expression in oncogene-induced senescence.

ATM Inhibition Synergizes with Fenofibrate in High Grade Serous Ovarian Cancer Cells

This study shows that combining ATM inhibitors with fenofibrate improves treatment in high-grade serous ovarian cancer cells by inducing senescence.

ATM inhibition drives metabolic adaptation via induction of macropinocytosis

This study shows that ATM inhibition promotes cancer cell survival by increasing macropinocytosis, which can be suppressed by BCAA supplementation.

Suppression of p16 increases nucleotide synthesis via mTORC1

This study shows that p16 suppression increases nucleotide synthesis through mTORC1 activation, promoting tumorigenesis by bypassing senescence.

Targeting IDH1 as a pro-senescent therapy in high-grade serous ovarian cancer

This study identifies IDH1 as a therapeutic target in HGSC by showing its role in promoting metabolic adaptation and epigenetic repression, leading to senescence when inhibited.