M. Yoshioka

NADPH oxidase-mediated sulfenylation of cysteine derivatives is key regulatory events for plant immune responses

This study shows that NADPH oxidase-generated ROS sulfenylates cysteine residues in ROS sensor proteins, regulating plant immune responses like cell death and pathogen defense.

Evolution of wheat blast resistance gene Rmg8 accompanied by differentiation of variants recognizing the powdery mildew fungus

The paper traces the evolutionary origin of wheat blast resistance gene Rmg8 and shows its ability to recognize both wheat blast and powdery mildew pathogens.

Breeding of a near-isogenic wheat line resistant to wheat blast at both seedling and heading stages through incorporation of Rmg8

This study introduces Rmg8 into a wheat cultivar to create near-isogenic lines resistant to wheat blast at both seedling and heading stages, showing broader resistance than existing genetic resources.

Ameliorative effect of a quinazoline-based bromodomain inhibitor, CN210, on experimentally-induced Crohn's disease-like murine ileitis via inhibition of inflammatory cytokine expression

This study shows that CN210, a quinazoline-based BET inhibitor, reduces inflammation in a murine model of Crohn's disease by inhibiting inflammatory cytokine expression and NF-κB/MAP kinase pathways.

Three-dimensional cultured Liver-on-a-Chip with mature hepatocyte-like cells derived from human pluripotent stem cells

This paper develops a simple Liver-on-a-Chip platform using hPSC-derived hepatocyte-like cells, showing improved hepatic function and maturation.