Author

J. W. Botten

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 4 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Organism:mouse· 1

Frequent Co-Authors

A. Whitaker· 2 shared E. A. Bruce· 2 shared P. Eisenhauer· 2 shared A. Falcone· 1 shared A. Jaochimiak· 1 shared A. K. Ramesh· 1 shared A. L. Greninger· 1 shared A. M. Schmoker· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersMicrobiology

A. Whitaker

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

An ACE2 decamer viral trap as a durable intervention solution for current and future SARS-CoV

H. Guo, B. Cho, P. R. Hinton, S. He, Y. Yu, A. K. Ramesh, J. P. Sivaccumar, Z. Ku, K. Campo, S. Holland, S. Sachdeva, C. Mensch, M. Dawod, A. Whitaker, P. Eisenhauer, , T.-M. Fu

This paper introduces an ACE2 decamer viral trap that neutralizes multiple SARS-CoV-2 variants and related coronaviruses through inhalation, showing durability and effectiveness in preclinical models.

bioRxiv · Jul 10, 2023Microbiology

A global map of the Zika virus phosphoproteome reveals host-driven regulation of viral budding and cytopathogenicity

I. Manuelyan, A. M. Schmoker, B. L. Yount, P. Eisenhauer, J. I. Keller, C. Gold, D. Terino, C. M. Ziegler, J. Alexander, H. E. Driscoll, E. Hutchinson, D. Bhella, C. D. Syme, D. G. Widman, M. T. Heise, , J. W. Botten

This study maps host-driven post-translational modifications on the Zika virus proteome, identifies key phosphosites, and shows how an FDA-approved kinase inhibitor blocks viral growth.

bioRxiv · Nov 24, 2021 · PreprintMicrobiology

SARS-CoV-2 triggers DNA damage response in Vero E6 cells

J. Victor, J. Deutsch, A. Whitaker, E. N. Lamkin, A. March, P. Zhou, J. W. Botten, N. Chatterjee

This study shows SARS-CoV-2 infection induces a DNA damage response in Vero E6 cells, including upregulated ATR, phosphorylated CHK1 and H2AX, and reduced TRF2 and telomere length.

bioRxiv · Sep 8, 2021Cancer Biology

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro

N. Drayman, K. A. Jones, S.-A. Azizi, H. M. Froggatt, K. Tan, N. Ivanova Maltseva, S. Chen, V. Nicolaescu, S. Dvorkin, K. Furlong, R. S. Kathayat, M. R. Firpo, V. Mastrodomenico, E. A. Bruce, M. M. Schmidt, , S. Tay

The paper screens 1,900 drugs to find inhibitors of SARS-CoV-2 replication, identifies masitinib as a 3CLpro inhibitor effective in vitro, and shows its broad anti-viral activity.

bioRxiv · Aug 31, 2020Microbiology

DIRECT RT-qPCR DETECTION OF SARS-CoV-2 RNA FROM PATIENT NASOPHARYNGEAL SWABS WITHOUT AN RNA EXTRACTION STEP

E. A. Bruce, M.-L. Huang, G. A. Perchetti, S. Tighe, J. J. Hoffman, P. Laaguiby, D. L. Gerrard, A. Nalla, Y. Wei, A. L. Greninger, S. A. Diehl, D. J. Shirley, D. G. B. Leonard, C. D. Huston, B. D. Kirkpatrick, , J. W. Botten

This paper tests a direct RT-qPCR method for detecting SARS-CoV-2 RNA in nasal swabs without RNA extraction, achieving 92% accuracy on blinded samples.

bioRxiv · Mar 20, 2020Microbiology