A PI(3,5)P2/ESCRT-III axis terminates STING signalling by facilitating TSG101-mediated lysosomal microautophagy
T. Taguchi, T. Shoji, A. Shinojima, S. Kusumi, D. Koga, K. Mukai, J. Nakayama, S. Higashiyama, Y. Kuchitsu
This study identifies the PI(3,5)P2/ESCRT-III axis as essential for STING degradation via lysosomal microautophagy, preventing sustained type I interferon responses.
bioRxiv · May 26, 2024 · PreprintCell Biology