S. Wakabayashi

Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model

This paper develops an engineered Mycobacterium tuberculosis strain with kill switches for a safe TB human challenge model, showing rapid clearance and low escape rates.

The cholesterol pathway of the Golgi stress response induces cell death and transcription of Golgi-related genes through metabolic dysregulation of phosphatidylinositol-4-phosphate

Expression of transcription factors KLF2 and KLF4 is induced by the mammalian Golgi stress response

The paper identifies KLF2 and KLF4 as transcription factors induced by PG-type Golgi stress and involved in regulating proteoglycan pathways.

Attenuated Mycobacterium tuberculosis Vaccine Protection in a Low Dose Murine Challenge Model

This study shows that the live attenuated Mtb vaccine candidate ΔLprG provides better protection than BCG in a low dose murine challenge model, reducing detectable infection and containing it anatomically.

Rv3722c governs aspartate-dependent nitrogen metabolism in Mycobacterium tuberculosis

This study identifies Rv3722c as the primary aspartate aminotransferase in Mtb, revealing its role in nitrogen distribution and highlighting it as a potential drug target.

MGSE regulates crosstalk from the mucin pathway to the TFE3 pathway of the Golgi stress response

The paper identifies a novel mucin pathway that enhances glycosylation enzyme expression during mucin-type Golgi stress and shows it activates the TFE3 pathway through a specific enhancer element.

Large-scale chemical-genetics yields new Mycobacterium tuberculosis inhibitor classes

This study uses a novel chemical-genetics screening strategy to identify new inhibitors of Mycobacterium tuberculosis, revealing novel compound classes targeting previously unexplored bacterial targets.