J. Nakayama

Metastatic potentials classified with hypoxia-inducible factor 1 downstream gene in pan-cancer cell lines

The paper classifies metastatic potentials in cancer cell lines using HIF1 downstream gene expression patterns across 30 cancer types.

Targeting c-Jun is a potential therapy of luminal breast cancer bone metastasis

This study identifies c-Jun as a novel marker for luminal breast cancer bone metastasis and shows its inhibition reduces metastatic potential.

Aberrant regulation of serine metabolism drives extracellular vesicle release and cancer progression

This study identifies miR-891b and PSAT1 as regulators of EV secretion and cancer progression through the serine-ceramide pathway.

A zebrafish embryo screen utilizing gastrulation for identification of anti-metastasis drugs

The paper presents a zebrafish embryo-based screen for anti-metastasis drugs using gastrulation as a model, identifying Adrenosterone and Pizotifen as potential candidates.

Expressional Diversity and Cancer-prone Phenotypes in Cigarette-smoking Lungs at Single Cell Resolution

This study uses scMeta-analysis to integrate public scRNA-seq data from smoking lungs, revealing expressional diversity and aging-related gene expression differences linked to smoking-induced carcinogenesis.

Identification of two cancer stem cell-like populations in triple-negative breast cancer xenografts

The paper identifies two cancer stem cell-like populations in TNBC xenografts using transcriptomic analysis and confirms their presence in patient data, suggesting potential as biomarkers and implications for drug resistance.

Metastatic profiling of HER2-positive breast cancer cell lines in xenograft models

This study evaluates the metastatic abilities of HER2-positive breast cancer cell lines in xenograft models and identifies gene signatures associated with metastatic preferences.

HSD11β1 promotes EMT-mediated breast cancer metastasis

This study identifies HSD11β1 as a promoter of breast cancer metastasis via EMT induction and shows that targeting HSD11β1 could suppress metastasis.

Aberrant accumulation of NIK promotes tumorigenicity by dysregulating post-translational modifications in breast cancer

This study identifies NIK upregulation in breast cancer due to translational dysregulation, which promotes tumorigenicity by activating the non-canonical NF-κB pathway.

HOXB7 induces STAT3-mediated transformation and lung metastasis in immortalized mammary gland NMuMG cells

This study shows HOXB7 promotes transformation and lung metastasis in NMuMG cells via STAT3 activation.

Cinnamon bark extract suppresses metastatic dissemination of cancer cells through inhibition of glycolytic metabolism

Cinnamon bark extract suppresses cancer cell metastasis by inhibiting glycolytic metabolism, as shown through zebrafish models and metabolomic analysis.