H. Koga

Zinc finger domains bind low-complexity domain polymers

This study shows zinc finger domains bind low-complexity domain polymers in a cross-β-dependent manner, suppressing polymer formation and preferentially recognizing polymeric LC domains.

Experimental validation of the mechanism of stomatal development diversification

The study validates a model of stomatal development diversification by altering MUTE expression timing in Arabidopsis, generating plants with altered meristemoid behavior and morphology.

Catalytic antibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin and impair cardiomyocyte cohesion

This study shows that catalytic autoantibodies in arrhythmogenic cardiomyopathy patients cleave desmoglein 2 and N-cadherin, impairing cardiomyocyte cohesion through p38MAPK activation.

A bispecific antibody NXT007 exerts a hemostatic activity in hemophilia A monkeys enough to keep a non-hemophiliac state

This paper reports a bispecific antibody NXT007 that shows improved hemostatic activity in hemophilia A monkeys, equivalent to FVIII levels, with lower dosing requirements and longer intervals.

Red-beet betalain pigment inhibits amyloid-β aggregation and toxicity in amyloid-β expressing Caenorhabditis elegans model

This study shows red-beet betalain pigments inhibit amyloid-β aggregation and toxicity in a C. elegans model of Alzheimer's disease.

The molecular framework of heterophylly in Callitriche palustris L. differs from that in other amphibious plants

This study investigates the molecular and developmental mechanisms of heterophylly in Callitriche palustris, revealing hormonal and transcriptional differences from other amphibious plants.

Oxicam-type NSAIDs enhance Agrobacterium-mediated transformation in plants

This study shows oxicam-type NSAIDs like tenoxicam enhance Agrobacterium-mediated transformation in plants by temporarily suppressing immune responses, improving both transient and stable transformation efficiency.