J. Gaddy

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights into MFN-2 Mediated Changes

This study investigates age-related changes in mitochondrial 3D structure in human skeletal muscle and shows that exercise can restore mitochondrial integrity through mitofusin 2.

Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes

This study shows that Sam50 deficiency in myotubes leads to mitochondrial fragmentation, altered metabolism, and impaired oxidative capacity in both mice and humans.

Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue

This study uses 3D electron microscopy to analyze mitochondrial cristae morphology in mouse brown adipose tissue across aging, finding significant structural changes in aged tissue.

Streptococcus agalactiae npx is required for survival in human placental macrophages and full virulence in a model of ascending vaginal infection during pregnancy

This study shows that the NADH peroxidase gene npx in Streptococcus agalactiae is essential for survival in placental macrophages and virulence in a pregnancy-related infection model.

Group B streptococcal membrane vesicles induce proinflammatory cytokine production and are sensed in an NLRP3 inflammasome-dependent mechanism in human macrophages

This study shows that GBS membrane vesicles induce proinflammatory cytokines in macrophages via NLRP3 inflammasome-dependent mechanisms, suggesting potential for immunotherapeutic targeting.

Production and composition of group B streptococcal membrane vesicles varies across diverse lineages

This study quantifies membrane vesicle production and protein composition across diverse GBS strains, finding lineage-dependent variation in MVs that may influence clinical outcomes.

Streptococcus agalactiae induces placental macrophages to release extracellular traps loaded with tissue remodeling enzymes via an oxidative-burst-dependent mechanism

This paper shows that placental macrophages release extracellular traps containing enzymes that kill GBS and may contribute to fetal membrane damage during infection.