Author

D. M. Hutt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Organism:mouse· 1

Frequent Co-Authors

W. E. Balch· 3 shared A. C. McQuattie-Pimentel· 1 shared A. Rosa Campos· 1 shared A. V. Misharin· 1 shared B. Tait· 1 shared C. Dickey· 1 shared D. Culbertson· 1 shared G. R. S. Budinger· 1 shared

Activity by Year

2018-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

W. E. Balch

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Proteostasis and Energetics as Proteome Hallmarks of Aging and Influenza Challenge in Pulmonary Disease

S. Loguercio, D. M. Hutt, A. Rosa Campos, T. Stoeger, R. A. Grant, A. C. McQuattie-Pimentel, H. Abdala-Valencia, Z. Lu, N. Joshi, K. Ridge, N. S. Chandel, J. I. Sznajder, R. I. Morimoto, A. V. Misharin, G. R. S. Budinger, W. E. Balch

This study examines proteome changes in alveolar macrophages and type 2 cells from young and old mice before and after influenza infection, revealing age-related proteostasis and mitochondrial dysfunction that worsen with infection.

bioRxiv · Sep 14, 2019 · PreprintCell Biology

Correction of Niemann-Pick type C1 disease with the histone deacetylase inhibitor valproic acid

K. Subramanian, D. M. Hutt, V. Gupta, S. Mao, W. E. Balch

This study shows valproic acid corrects the folding and trafficking defect of the I1061T-NPC1 mutation, restoring cholesterol homeostasis and suggesting a potential therapeutic approach for Niemann-Pick type C disease.

bioRxiv · Aug 4, 2019Cell Biology

Management of Hsp90-Dependent Protein Folding by Small Molecule Targeting the Aha1 Co-Chaperone

J. K. Singh, B. Tait, N. Guy, J. C. Sivils, D. Culbertson, C. Dickey, S. Y. Kuo, J. E. Gestwicki, D. M. Hutt, J. H. Dyson, M. B. Cox, W. E. Balch

This study identifies SEW04784, a small molecule that disrupts Aha1-stimulated Hsp90 ATPase activity, showing therapeutic potential in prostate cancer and tauopathies without affecting basal Hsp90 function.

bioRxiv · Sep 11, 2018Biochemistry