G. R. S. Budinger

Prolonged exposure to lung-derived cytokines is associated with inflammatory activation of microglia in patients with COVID-19

The paper shows that prolonged exposure to lung-derived cytokines in COVID-19 patients activates microglia, and corticosteroids reduce this inflammatory response.

Myeloid Zfhx3 Deficiency Protects Against Hypercapnia-induced Suppression of Host Defense Against Influenza A Virus

The paper shows that Zfhx3 deficiency in myeloid cells protects mice from hypercapnia-induced immune suppression and worsens influenza A virus infection.

Hypercapnia limits β-catenin mediated alveolar type 2 cell progenitor function by altering Wnt production from adjacent fibroblasts

This study shows hypercapnia inhibits β-catenin signaling in alveolar type 2 cells by altering Wnt production from fibroblasts, impairing lung repair after injury.

Pharmacological inhibition of PAI-1 alleviates cardiopulmonary pathologies induced by exposure to air pollutants PM2.5

This study shows that inhibiting PAI-1 with TM5614 reduces PM2.5-induced cardiopulmonary and vascular damage in both in vivo and in vitro models.

Hypercapnia Suppresses Macrophage Antiviral Activity and Increases Mortality of Influenza A 1 Infection via Akt1

This study shows hypercapnia suppresses macrophage antiviral activity and increases influenza A mortality via Akt1 activation in mice.

Proteostasis and Energetics as Proteome Hallmarks of Aging and Influenza Challenge in Pulmonary Disease

This study examines proteome changes in alveolar macrophages and type 2 cells from young and old mice before and after influenza infection, revealing age-related proteostasis and mitochondrial dysfunction that worsen with infection.