D. J. Kelly

Engineering High-Quality Cartilage Microtissues using Hydrocortisone Functionalised Microwells

This paper develops a method to generate high-quality cartilage microtissues using hydrocortisone-functionalized microwells and identifies hydrocortisone as a key factor enhancing chondrogenic differentiation of MSCs.

Temporal enzymatic treatment to enhance the remodelling of multiple cartilage microtissues into a structurally organised tissue

This study shows that temporal enzymatic treatment improves the structural organisation of engineered cartilage grafts made from multiple microtissues.

Integrating melt-electrowriting and inkjet bioprinting for engineering structurally organized articular cartilage

This paper develops a hybrid bioprinting method combining melt-electrowriting and inkjet bioprinting to create structurally organized articular cartilage grafts with improved mechanical properties.

A two-hit epistasis model prevents core genome disharmony in recombining bacteria

The paper shows that recombination in bacteria can overcome genomic disharmony through a two-hit epistasis model, allowing beneficial gene combinations to be reinstated in new genetic backgrounds.

Badger territoriality maintained despite disturbance of major road construction

The study monitors badger ranging behavior before, during, and after road construction to assess impacts on territoriality and tuberculosis spread, finding minimal behavioral changes.

Effects of chondrogenic priming duration on mechanoregulation of engineered cartilage anlagen.

This study investigates how the duration of chondrogenic priming affects the response of engineered cartilage anlagen to dynamic mechanical compression, showing that priming duration modulates mechanical and biochemical outcomes.

Marcksl1 modulates endothelial cell mechanoresponse to haemodynamic forces to control blood vessel shape and size

This study shows that Marcksl1 modulates endothelial cell mechanical responses to blood flow, affecting vessel size and shape during angiogenesis.

The cryo-EM structure of the bacterial flagellum cap complex suggests a molecular mechanism for filament elongation.

The paper reports the cryo-EM structure of the Campylobacter jejuni flagellum cap complex and proposes a model for filament-cap interaction.

Domestication of Campylobacter jejuni NCTC 11168

This study compares genetic and phenotypic variation in 23 isolates of the reference Campylobacter jejuni strain NCTC 11168, showing significant genomic and phenotypic differences despite being considered identical.

Recapitulating bone development for tissue regeneration through engineered mesenchymal condensations and mechanical cues

This study shows that mechanical loading enhances bone regeneration through engineered mesenchymal condensations, mimicking endochondral ossification without heterotopic bone formation.