Author

D. R. Hicks

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:protein design· 2 Assay:protein structure· 2 Research Focus:cell signaling & trafficking· 1 Organism:E. coli· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

D. Baker· 3 shared B. Coventry· 2 shared G. Bhabha· 2 shared I. Goreshnik· 2 shared L. Stewart· 2 shared A. A. Vorobieva· 1 shared A. Broerman· 1 shared A. Etemadi· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

D. Baker

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Author profile →

3 papers

Recent·Most cited

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

N. I. Edman, R. L. Redler, A. Phal, T. Schlichthaerle, S. R. Srivatsan, A. Etemadi, S. An, A. Favor, D. Ehnes, Z. Li, F. Praetorius, M. Gordon, W. Yang, B. Coventry, D. R. Hicks, , D. Baker

This study designs synthetic oligomeric ligands to modulate FGFR signaling and shows their impact on vascular cell fate decisions.

Cell · Jul 1, 2024Peer-reviewedBioengineering

De novo design of diverse small molecule binders and sensors using Shape Complementary Pseudocycles

L. An, M. Said, L. Tran, S. Majumder, I. Goreshnik, G. R. Lee, D. Juergens, J. Dauparas, I. Anishchenko, B. Coventry, A. K. Bera, A. Kang, P. M. Levine, V. Alvarez, A. Pillai, , D. Baker

The paper designs nanomolar binders for diverse small molecules using a pseudocycle-based shape complementarity method, enabling direct conversion into sensing systems.

bioRxiv · Dec 20, 2023 · PreprintBiochemistry

De novo design of modular peptide binding proteins by superhelical matching

K. Wu, H. Bai, Y.-T. Chang, R. Redler, K. E. McNally, W. Sheffler, T. Brunette, D. R. Hicks, T. E. Morgan, T. J. Stevens, A. Broerman, I. Goreshnik, M. DeWitt, C. M. Chow, Y. Shen, , D. Baker

This paper introduces a method to design modular peptide binding proteins that bind repeating peptide sequences with high specificity and affinity.

bioRxiv · Nov 14, 2022 · PreprintBiochemistry