Author

T. Brunette

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Bioengineering· 1

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Research Focus:protein design· 4 Approach:deep learning· 3 Approach:experimental assay· 3 Assay:protein structure· 3 Research Focus:protein structure prediction· 2 Approach:statistical model· 2 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

D. Baker· 5 shared A. K. Bera· 3 shared A. Kang· 3 shared G. Bhabha· 3 shared A. Courbet· 2 shared A. J. Borst· 2 shared B. Sankaran· 2 shared C. M. Chow· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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5 shared papersBiochemistry

D. Baker

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Author profile →

5 papers

Recent·Most cited

De novo design of buttressed loops for sculpting protein functions

H. Jiang, K. M. Jude, K. Wu, J. Fallas, G. Ueda, T. Brunette, D. Hicks, H. Pyles, A. Yang, L. Carter, M. Lamb, X. Li, P. M. Levine, L. J. Stewart, K. C. Garcia, D. Baker

This paper designs proteins with structured loops supported by hydrogen bonds, demonstrating their stability and functionality in binding extended peptides.

bioRxiv · Aug 22, 2023 · PreprintBiochemistry

Blueprinting expandable nanomaterials with standardized protein building blocks

T. F. Huddy, Y. Hsia, R. D. Kibler, J. Xu, N. Bethel, D. Nagarajan, R. Redler, P. J. Y. Leung, A. Courbet, E. C. Yang, A. K. Bera, N. Coudray, S. J. Calise, F. A. Davila-Hernandez, C. Weidle, , D. Baker

This paper introduces standardized protein building blocks and geometric design principles to create expandable protein nanomaterials, validated through X-ray crystallography and electron microscopy.

bioRxiv · Jun 9, 2023Biochemistry

De novo design of modular peptide binding proteins by superhelical matching

K. Wu, H. Bai, Y.-T. Chang, R. Redler, K. E. McNally, W. Sheffler, T. Brunette, D. R. Hicks, T. E. Morgan, T. J. Stevens, A. Broerman, I. Goreshnik, M. DeWitt, C. M. Chow, Y. Shen, , D. Baker

This paper introduces a method to design modular peptide binding proteins that bind repeating peptide sequences with high specificity and affinity.

bioRxiv · Nov 14, 2022 · PreprintBiochemistry

Precisely patterned nanofibers made from extendable protein multiplexes

N. P. Bethel, A. J. Borst, F. Parmeggiani, M. J. Bick, T. Brunette, H. Nguyen, A. Kang, A. K. Bera, L. Carter, M. C. Miranda, R. Kibler, M. Lamb, X. Li, B. Sankaran, D. Baker

The paper designs extendable protein multiplexes with symmetric architectures to create precisely patterned nanofibers through controlled repeat propagation and hydrophilic patch placement.

bioRxiv · Oct 14, 2022 · PreprintBioengineering

Hierarchical design of multi-scale protein complexes by combinatorial assembly of oligomeric helical bundle and repeat protein building blocks

Y. Hsia, R. Mout, W. Sheffler, N. I. Edman, I. Vulovic, Y.-J. Park, R. L. Redler, M. J. Bick, A. K. Bera, A. Courbet, A. Kang, T. Brunette, U. Nattermann, E. Tsai, A. Saleem, , D. Baker

This paper describes a hierarchical method to design multi-scale symmetric protein complexes using repeat proteins and helical bundles, resulting in large symmetric assemblies like an icosahedral nanocage.

bioRxiv · Jul 27, 2020Biochemistry