Author

R. Roychoudhuri

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. Aghemo· 1 shared A. Bartlett· 1 shared A. Lleo· 1 shared A. Termanini· 1 shared B. Bilanges· 1 shared B. C. Kennedy· 1 shared B. Franceschini· 1 shared B. Vanhaesebroeck· 1 shared

Activity by Year

2022-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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1 shared paperImmunology

A. Aghemo

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Author profile →

4 papers

Recent·Most cited

Lack of phosphatidylinositol 3-kinase VPS34 in regulatory T cells leads to a fatal lymphoproliferative disorder without affecting their development

C. J. Courreges, E. C. Davenport, B. Bilanges, E. Rebollo-Gomez, J. Hukelmann, P. Schoenfelder, J. R. Edgar, D. Sansom, C. Scudamore, R. Roychoudhuri, O. A. Garden, B. Vanhaesebroeck, K. Okkenhaug

This study shows that VPS34 deficiency in regulatory T cells causes a fatal lymphoproliferative disorder by impairing metabolic and functional processes, despite normal development and in vitro suppression.

bioRxiv · Jan 8, 2024Immunology

Intracellular K+ limits T cell exhaustion and preserves antitumor function

C. Collier, K. Wucherer, M. Mcwhorter, C. Jenkins, A. Bartlett, R. Roychoudhuri, R. Eil

This study shows that lowering intracellular K+ in T cells by disrupting Na+/K+ ATPase reduces T cell exhaustion and improves antitumor function by mitigating ROS accumulation.

bioRxiv · Sep 13, 2023Immunology

Time-, tissue- and treatment-associated heterogeneity in tumour-residing migratory DCs

C. Y. Lee, B. C. Kennedy, N. Richoz, I. Dean, Z. K. Tuong, F. Gaspal, Z. Li, C. Willis, T. Hasegawa, S. K. Whiteside, D. A. Posner, G. Carlesso, S. A. Hammond, S. Dovedi, R. Roychoudhuri, , M. R. Clatworthy

This study identifies heterogeneous tumor-residing migratory dendritic cells (mRegDCs) that show distinct transcriptional and functional profiles, impacting anti-tumor immune responses.

bioRxiv · Jul 3, 2023Immunology

Multimodal single-cell profiling of intrahepatic cholangiocarcinoma defineshyperactivated Tregs as a potential therapeutic target

G. Alvisi, A. Termanini, C. Soldani, F. Portale, R. Carriero, K. Pilipow, M. Polidoro, B. Franceschini, I. Malenica, S. Puccio, V. Lise, V. Zanon, F. S. Colombo, M. Tufano, C. Peano, , A. Lleo

This study identifies hyperactivated Tregs in iCCA as a therapeutic target through multimodal single-cell profiling of immune infiltrates.

bioRxiv · Mar 6, 2022Immunology