Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy
J. Chen, Z. Amoozgar, X. LIU, S. Aoki, Z. Liu, S. Shin, A. Matsui, Z. Pu, P.-J. Lei, M. Datta, L. Zhu, Z. Ruan, L. Shi, D. Staiculescu, K. Inoue, , D. G. Duda
This paper shows that combining chemotherapy with CTLA-4 blockade reprograms the immune microenvironment of intrahepatic cholangiocarcinoma, enhancing the effectiveness of anti-PD1 therapy.
bioRxiv · Jan 26, 2023Cancer Biology