Author

L. L. Munn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Assay:clinical cohort / trial· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

P.-J. Lei· 3 shared H. Zhou· 2 shared J. J. Rajotte· 2 shared J. M. Ubellacker· 2 shared J. W. Baish· 2 shared L. Menzel· 2 shared M. J. O'Melia· 2 shared M. S. Razavi· 2 shared

Activity by Year

2023-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCancer Biology

P.-J. Lei

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Author profile →

3 papers

Recent·Most cited

Lymphatic muscle cells are unique cells that undergo aging induced changes

P.-J. Lei, K. J. Ruscic, K. Roh, J. J. Rajotte, M. J. O'Melia, E. M. Bouta, M. Marquez, E. R. Pereira, A. S. Kumar, G. Arroyo-Ataz, M. S. Razavi, H. Zhou, L. Menzel, H. Kumra, M. Duquette, , T. P. Padera

This study creates a single-cell transcriptomic atlas of lymphatic muscle cells in mice across ages, revealing age-related transcriptional changes and a pro-inflammatory environment in aged cells.

bioRxiv · Nov 18, 2023Cell Biology

Distant lymph nodes compensate for resected tumor-draining lymph nodes during cancer immunotherapy

L. Menzel, H. Zhou, J. W. Baish, M. J. O'Melia, L. B. Darragh, E. Specht, D. N. Effiom, J. Czapla, P.-j. Lei, J. J. Rajotte, L. Liu, M. R. Nikmaneshi, M. S. Razavi, M. G. Vander Heiden, J. M. Ubellacker, , T. P. Padera

The paper shows that removing tumor-draining lymph nodes does not impair immune checkpoint blockade response, as distant lymph nodes compensate for the loss.

bioRxiv · Sep 19, 2023Cancer Biology

Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy

J. Chen, Z. Amoozgar, X. LIU, S. Aoki, Z. Liu, S. Shin, A. Matsui, Z. Pu, P.-J. Lei, M. Datta, L. Zhu, Z. Ruan, L. Shi, D. Staiculescu, K. Inoue, , D. G. Duda

This paper shows that combining chemotherapy with CTLA-4 blockade reprograms the immune microenvironment of intrahepatic cholangiocarcinoma, enhancing the effectiveness of anti-PD1 therapy.

bioRxiv · Jan 26, 2023Cancer Biology