M. Datta

Simulating the Impact of Tumor Mechanical Forces on Glymphatic Networks in the Brain Parenchyma

This study simulates how brain tumor mechanical forces affect glymphatic transport in the brain parenchyma, showing increased stress and strain reduce CSF flow rates.

A Mem-dELISA platform for dual color and ultrasensitive digital detection of colocalized proteins on extracellular vesicles

The paper introduces a Mem-dELISA platform for ultrasensitive, dual-color detection of colocalized proteins on extracellular vesicles, demonstrating its application in cancer research.

Novel 3-D macrophage spheroid model reveals reciprocal regulation of immunomechanical stress and mechano-immunological response

This study shows macrophages generate mechanical stress in agarose gels and respond to environmental stiffness and cytokine signals.

Single-cell mechanical analysis reveals viscoelastic similarities between normal and neoplastic brain cells

This study compares the viscoelastic properties of normal and glioblastoma brain cells under shear stress, finding no significant differences in their mechanical behavior.

Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy

This paper shows that combining chemotherapy with CTLA-4 blockade reprograms the immune microenvironment of intrahepatic cholangiocarcinoma, enhancing the effectiveness of anti-PD1 therapy.

Losartan controls immune checkpoint blocker-induced edema and improves survival in glioblastoma

Losartan prevents ICB-induced cerebral edema and improves survival in glioblastoma mice, with a predictive immune signature identified.

Integrated genomic view of SARS-CoV-2 in India

The paper analyzes SARS-CoV-2 genomic data from India to trace introduction and local transmission, identifying multiple clades and highlighting the need for molecular surveillance.

Shortwave Infrared Fluorescence Imaging with the Clinically Approved Near-Infrared Dye Indocyanine Green

This paper demonstrates that FDA-approved NIR dyes like ICG can be used for SWIR fluorescence imaging in vivo, enabling high-contrast imaging beyond 1500 nm with potential clinical applications.