SHP2 binds directly to SOS1 to enable RAS activation
Toshiyuki Araki, Yashika Agrawal, Sachin S. Katti, Hiep L.D. Nguyen, Daniel Pushparaju Yeggoni, Mitchell J. Geer, Wei Wei, Daniëlle T.J. Woutersen, Tieme Bijlsma, Cameron Genxuan Lian, Natalie M. Clark, Namrata D. Udeshi, Steven A. Carr, Heidi Stuhlmann, Michael A. Davies, , Wolfgang Peti
This paper identifies a PTP activity-independent mechanism by which SHP2 promotes RAS/ERK activation through direct binding to SOS1.
bioRxiv · Jun 13, 2026 · PreprintCancer Biology