Eli Rothenberg

This paper identifies a PTP activity-independent mechanism by which SHP2 promotes RAS/ERK activation through direct binding to SOS1.

The paper shows Pol{theta} is recruited via RAD51 ubiquitylation to resolve clustered ICLs causing replication fork collapse in HR-proficient cells.

The paper shows that inactive PARP2 causes Tp53-dependent lethal anemia by blocking replication-associated nick ligation in erythroblasts, explaining PARPi-induced hematological toxicities.

This study identifies the SAP domain of Ku70 as limiting KU lateral movement on DNA, with DNA-PKcs partially masking this function in NHEJ.

ORC1 binds to cis-transcribed RNAs from genes with replication origins at TSSs, which is required for optimal origin activation.

The paper uses super-resolution microscopy to visualize replication fork structures under stress and identifies proteins involved in their repair.

The paper introduces a method to quantify molecular interactions using stochastic modeling and super-resolution microscopy, validated with simulated and experimental data.