Cyclin D-CDK4/6 couple proliferation to membrane and mitochondrial protein supply through a DeSI1 phospho-switch
Sharon Kaisari, Ethan Lane, Raymond Wang, Jeffrey Estrada, Marta Collu, Daniele Simoneschi, Yeon‐Tae Jeong, Mengxi Liu, Qingyue Zhang, Yuki Kito, Ifat Abramovich, Jason Yin, Tori C. Rodrick, Gyles Ward, Tyler C. Cropley, , Michele Pagano
This study identifies DeSI1 as a cyclin D-CDK4/6 substrate whose phosphorylation regulates membrane and mitochondrial protein supply during proliferation.
bioRxiv · Sep 18, 2026 · PreprintCell Biology