Author

D. Lingwood

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 8

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 6 Organism:mouse· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2

Frequent Co-Authors

A. B. Balazs· 5 shared A. G. Schmidt· 5 shared B. M. Hauser· 5 shared E. C. Lam· 4 shared J. Feldman· 4 shared L. Ronsard· 4 shared M. Sangesland· 4 shared K. J. St. Denis· 3 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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5 shared papersImmunology

A. B. Balazs

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Author profile →

8 papers

Recent·Most cited

Lupus-associated innate receptors drive extrafollicular evolution of autoreactive B cells

D. Y.-D. Zhu, D. P. Maurer, C. Castrillon, Y. Deng, F. A. N. Mohamed, M. Ma, A. G. Schmidt, D. Lingwood, M. C. Carroll

This study investigates the role of lupus-associated innate receptors in the extrafollicular development of autoreactive B cells using adoptive transfer and time-stamped analysis in a mouse model.

bioRxiv · Jan 9, 2024 · PreprintImmunology

A modular platform to display multiple hemagglutinin subtypes on a single immunogen

D. T. Lamson, F. A. N. Mohamed, M. Vu, D. P. Maurer, L. Ronsard, D. Lingwood, A. G. Schmidt

This paper introduces a modular immunogen platform that displays multiple hemagglutinin subtypes and elicits cross-reactive immune responses against influenza subtypes not included in the immunogen.

bioRxiv · Nov 9, 2023 · PreprintImmunology

Heterologous sarbecovirus receptor binding domains as scaffolds for SARS-CoV-2 receptor binding motif presentation

B. M. Hauser, M. Sangesland, E. C. Lam, K. J. St. Denis, M. L. Sheehan, M. L. Vu, A. H. Cheng, A. B. Balazs, D. Lingwood, A. Schmidt

This study designs immunogens by grafting SARS-2 RBM onto heterologous sarbecovirus scaffolds to elicit broad neutralizing antibodies against sarbecoviruses.

bioRxiv · Aug 21, 2023Immunology

Enhancing antibody responses by multivalent antigen display on thymus-independent DNA origami scaffolds

E.-C. Wamhoff, L. Ronsard, J. Feldman, G. A. Knappe, B. M. Hauser, A. Romanov, E. Lam, K. St. Denis, J. Boucau, A. K. Barczak, A. B. Balazs, A. Schmidt, D. Lingwood, M. Bathe

This study shows DNA origami scaffolds enhance antibody responses to SARS-CoV-2 RBD without inducing immune memory against the scaffold itself, compared to protein-based VLPs.

bioRxiv · Aug 16, 2022Immunology

Antigen identification and high-throughput interaction mapping by reprogramming viral entry

C. S. Dobson, A. N. Reich, S. Gaglione, B. E. Smith, E. J. Kim, J. Dong, L. Ronsard, V. Okonkwo, D. Lingwood, M. Dougan, S. K. Dougan, M. E. Birnbaum

This paper introduces RAPTR, a method to identify antigens and map their interactions with immune receptors using viral pseudotyping and single-cell sequencing.

bioRxiv · Sep 18, 2021Immunology

Rationally designed immunogens enable immune focusing to the SARS-CoV-2 receptor binding motif

B. M. Hauser, M. Sangesland, K. J. St. Denis, I. W. Windsor, J. Feldman, E. C. Lam, T. Kannegieter, A. B. Balazs, D. Lingwood, A. G. Schmidt

This study designs immunogens that focus immune responses to the SARS-CoV-2 receptor binding motif, enhancing neutralizing antibody breadth against related sarbecoviruses.

bioRxiv · Mar 15, 2021 · PreprintImmunology

Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses

J. Feldman, J. Bals, C. Altomare, K. S. Denis, E. C. Lam, B. M. Hauser, L. Ronsard, M. Sangesland, T. B. Moreno, V. Okonkwo, N. Hartojo, A. B. Balazs, G. Bajic, D. Lingwood, A. G. Schmidt

The paper isolates naive B cells targeting SARS-CoV-2 RBD and shows they can neutralize the virus and variants.

bioRxiv · Feb 2, 2021Immunology

Engineered receptor binding domain immunogens elicit pan-sarbecovirus neutralizing antibodies

B. M. Hauser, M. Sangesland, E. C. Lam, K. J. St. Denis, J. Feldman, A. S. Yousif, T. M. Caradonna, T. Kannegieter, A. B. Balazs, D. Lingwood, A. G. Schmidt

This study shows that a cocktail of trimeric sarbecovirus receptor binding domains elicits broadly neutralizing antibodies against multiple sarbecoviruses, including in the context of prior SARS-CoV-2 immunity.

bioRxiv · Dec 7, 2020 · PreprintImmunology