A. Zhu

Senolytics enhance longevity in Caenorhabditis elegans by altering betaine metabolism

This study identifies betaine metabolism as a key factor in aging in C. elegans and shows that senolytics extend lifespan by increasing betaine levels and enhancing autophagy and antioxidant capacity.

Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability

This study shows that a Trem2 agonist increases plaque macrophage survival and proliferation while improving plaque stability by enhancing collagen deposition and reducing necrotic core size.

CTCF is essential for proper mitotic spindle structure and anaphase segregation

This study shows that CTCF is crucial for correct mitotic spindle structure and anaphase segregation, leading to abnormal nuclear morphology in interphase.

Trem2 Promotes Foamy Macrophage Lipid Uptake and Survival in Atherosclerosis

This study identifies Trem2 as a regulator of foamy macrophage differentiation and atherosclerotic plaque growth, showing its role in lipid uptake and cell survival.

Multi-environment QTL analysis delineates a major locus associated with homoeologous exchanges for water-use efficiency and seed yield in allopolyploid Brassica napus

This study identifies a major QTL on chromosome A09 associated with water-use efficiency and seed yield in Brassica napus, linked to homoeologous exchanges and gene expression differences.

Two microbiota subtypes identified in Irritable Bowel Syndrome with distinct responses to the low FODMAP diet

This paper identifies two IBS microbiota subtypes with distinct responses to the low FODMAP diet, showing that the pathogenic-like subtype responds better to dietary intervention.

Capsaicin activates TRPV1 in human Langerhans cells and inhibits mucosal HIV-1 transmission via secreted CGRP

This study shows that TRPV1 activation in Langerhans cells increases CGRP secretion, which inhibits HIV-1 trans-infection, suggesting TRPV1 agonists could be used as topical microbicides.

Adjuvanting a subunit SARS-CoV-2 nanoparticle vaccine to induce protective immunity in non-human primates

This study evaluates adjuvants for a subunit SARS-CoV-2 nanoparticle vaccine in non-human primates, showing durable neutralizing antibody responses and protection against infection.

Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 in nonhuman primates following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination

This study shows that NVX-CoV2373 vaccine induces antibodies with both neutralizing and Fc-effector functions, which together provide maximal protection against SARS-CoV-2 in non-human primates.

Impact of Ferumoxytol Magnetic Resonance Imaging on the Rhesus Macaque Maternal-Fetal Interface

Ferumoxytol-enhanced MRI does not affect histopathology or iron levels in the maternal-fetal interface of rhesus macaques during pregnancy or up to one year post-delivery.

Extensive genetic diversity of bat-borne polyomaviruses reveals inter-family host-switching events

This study identifies extensive genetic diversity of bat-borne polyomaviruses and reports three inter-family host-switching events, challenging the notion of strict host restriction in mammalian PyVs.

Highly multiplexed in situ protein imaging with signal amplification by Immuno-SABER

This paper introduces Immuno-SABER, a method for highly multiplexed protein imaging that overcomes limitations in sensitivity and throughput.

Enhanced Synthesis of Poly Gamma Glutamic Acid by Increasing the Intracellular Reactive Oxygen Species in the Bacillus licheniformis Δ1-pyrroline-5-carboxylate Dehydrogenase Gene ycgN Deficient Strain

This study shows that deleting the ycgN gene in B. licheniformis increases gamma-PGA synthesis by raising intracellular ROS levels through P5C accumulation.