HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA binding domain
E. E. Boczek, J. Fursch, L. Jawerth, M. Jahnel, M. L. Niedermeier, M. Ruer-Gruss, K.-M. Kammer, L. Mediani, J. Wang, X. Yan, A. Pozniakovski, I. Poser, D. Mateju, S. Carra, S. Alberti, , F. Stengel
This study identifies HspB8's role in preventing FUS condensate hardening by interacting with its RNA-binding domain, suggesting a mechanism to prevent neurodegenerative disease-associated phase transitions.
bioRxiv · Apr 13, 2021Biochemistry