M. Jahnel

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

GTPase-dependent cyclic flexibility transitions drive the two-component EEA1-Rab5 molecular motor

This study shows that Rab5 and EEA1 form a two-component molecular motor using GTP hydrolysis to drive cyclic flexibility transitions that perform mechanical work.

HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA binding domain

This study identifies HspB8's role in preventing FUS condensate hardening by interacting with its RNA-binding domain, suggesting a mechanism to prevent neurodegenerative disease-associated phase transitions.

The arrested state of processing bodies supports mRNA regulation in early development

This study shows that arrested P body condensates in Drosophila oocytes prevent premature mRNA release, supporting mRNA regulation during early development.

Thermal fluctuations assist mechanical signal propagation in coiled-coil proteins

The paper shows thermal fluctuations enable mechanical signal propagation in coiled-coil proteins through numerical simulations of a simplified Frenkel-Kontorova chain model.

Surface electrostatics govern the emulsion stability of biomolecular condensates

The paper investigates how surface electrostatics influence the stability of biomolecular condensates by comparing their fusion propensity using zeta potential measurements and molecular modeling.

Local Nucleation Of Microtubule Bundles Through Tubulin Concentration Into A Condensed Tau Phase

The paper shows that tau forms liquid droplets that concentrate tubulin, enabling local microtubule bundle nucleation without centrosomes.