S. Carra

Tardigrade small heat shock proteins can limit desiccation-induced protein aggregation

This study identifies and characterizes small heat shock proteins in tardigrades that improve desiccation tolerance by limiting protein aggregation.

Targeting the deNEDDylating enzyme NEDP1 to ameliorate ALS phenotypes through Stress Granules dissolution

This study shows that inhibiting NEDP1 reduces stress granules and improves cell survival in ALS models.

HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA binding domain

This study identifies HspB8's role in preventing FUS condensate hardening by interacting with its RNA-binding domain, suggesting a mechanism to prevent neurodegenerative disease-associated phase transitions.

BAG3 Pro209 mutants associated with myopathy and neuropathy relocate chaperones of the CASA-complex to aggresomes

This study shows that BAG3 Pro209 mutants cause aggresome formation and disrupt chaperone-assisted selective autophagy, leading to protein homeostasis loss regardless of clinical phenotype.

Protein products of non-stop mRNA disrupt nucleolar homeostasis

This study shows that nonstop mRNA proteins accumulate in nucleoli, disrupting their structure and function, and links this to neurodegeneration mechanisms.