Author

J. Fursch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. A. Hyman· 2 shared F. Stengel· 2 shared I. Poser· 2 shared M. Jahnel· 2 shared S. Alberti· 2 shared A. C. Murthy· 1 shared A. Hermann· 1 shared A. J. Baldwin· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

A. A. Hyman

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2 papers

Recent·Most cited

Small molecule modulation of a redox-sensitive stress granule protein dissolves stress granules with beneficial outcomes for familial amyotrophic lateral sclerosis models

H. Uechi, S. Sridharan, J. Nijssen, J. Bilstein, J. M. Iglesias-Artola, S. Kishigami, V. Casablancas-Antras, I. Poser, E. J. Martinez, E. Boczek, M. Wagner, N. Tomschke, A. M. de Jesus Domingues, A. Pal, T. Doeleman, , R. J. Wheeler

The paper identifies lipoamide as a small molecule that dissolves stress granules and improves outcomes in ALS models by modulating redox-sensitive proteins.

bioRxiv · Jan 5, 2024 · PreprintCell Biology

HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA binding domain

E. E. Boczek, J. Fursch, L. Jawerth, M. Jahnel, M. L. Niedermeier, M. Ruer-Gruss, K.-M. Kammer, L. Mediani, J. Wang, X. Yan, A. Pozniakovski, I. Poser, D. Mateju, S. Carra, S. Alberti, , F. Stengel

This study identifies HspB8's role in preventing FUS condensate hardening by interacting with its RNA-binding domain, suggesting a mechanism to prevent neurodegenerative disease-associated phase transitions.

bioRxiv · Apr 13, 2021Biochemistry