Author

L. Mediani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Organism:human· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

S. Carra· 3 shared S. Alberti· 2 shared A. A. Hyman· 1 shared A. Poletti· 1 shared A. Pozniakovski· 1 shared A. S. Holehouse· 1 shared B. Asselbergh· 1 shared B. Tedesco· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersCell Biology

S. Carra

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

HspB8 prevents aberrant phase transitions of FUS by chaperoning its folded RNA binding domain

E. E. Boczek, J. Fursch, L. Jawerth, M. Jahnel, M. L. Niedermeier, M. Ruer-Gruss, K.-M. Kammer, L. Mediani, J. Wang, X. Yan, A. Pozniakovski, I. Poser, D. Mateju, S. Carra, S. Alberti, , F. Stengel

This study identifies HspB8's role in preventing FUS condensate hardening by interacting with its RNA-binding domain, suggesting a mechanism to prevent neurodegenerative disease-associated phase transitions.

bioRxiv · Apr 13, 2021Biochemistry

BAG3 Pro209 mutants associated with myopathy and neuropathy relocate chaperones of the CASA-complex to aggresomes

E. Adriaenssens, B. Tedesco, L. Mediani, B. Asselbergh, V. Crippa, F. Antoniani, S. Carra, A. Poletti, V. Timmerman

This study shows that BAG3 Pro209 mutants cause aggresome formation and disrupt chaperone-assisted selective autophagy, leading to protein homeostasis loss regardless of clinical phenotype.

bioRxiv · Mar 5, 2020Cell Biology

Protein products of non-stop mRNA disrupt nucleolar homeostasis

Z. H. Davis, L. Mediani, J. Vinet, S. Alberti, A. S. Holehouse, S. Carra, O. Brandman

This study shows that nonstop mRNA proteins accumulate in nucleoli, disrupting their structure and function, and links this to neurodegeneration mechanisms.

bioRxiv · Nov 22, 2019 · PreprintCell Biology