E. H. Rego

Spatial segregation and aging of metabolic processes underlie phenotypic heterogeneity in mycobacteria

The paper identifies spatial segregation and aging-related changes in metabolic processes in mycobacteria, contributing to phenotypic heterogeneity.

A nucleoid-associated protein is involved in the emergence of antibiotic resistance by promoting the frequent exchange of the replicative DNA polymerase in M. smegmatis

This study identifies Lsr2 as a nucleoid-associated protein that promotes rapid exchange of the replicative DNA polymerase DnaE1 in M. smegmatis, enhancing DNA lesion repair but reducing antibiotic resistance.

An essential periplasmic protein coordinates lipid trafficking and is required for asymmetric polar growth in mycobacteria

This study identifies PgfA as a periplasmic protein essential for asymmetric polar growth in mycobacteria by coordinating lipid trafficking and cell wall synthesis.

Mycobacterial Serine/Threonine phosphatase PstP is phospho-regulated and localized to mediate control of cell wall metabolism

This study identifies PstP substrates and shows its phosphorylation regulates its activity in controlling cell wall metabolism in mycobacteria.

A conserved translation factor is required for optimal synthesis of a membrane protein family in mycobacteria

This study identifies LepA as a conserved GTPase that enhances the synthesis of mycobacterial porins, affecting drug tolerance and membrane permeability.