Marginated neutrophils in the lungs effectively compete for nanoparticles targeted to the endothelium, serving as a part of the reticuloendothelial system
M. E. Zamora, E.-O. Essien, K. Bhamidipati, A. Murthy, J. Liu, H. Kim, M. N. Patel, J. Nong, Z. Wang, C. Espy, F. Chaudhry, L. T. Ferguson, S. Tiwari, E. Hood, O. A. Marcos-Contreras, , J. S. Brenner
The paper shows that lung marginated neutrophils effectively uptake endothelial-targeted nanoparticles, suggesting they are part of the reticuloendothelial system.
bioRxiv · Jun 7, 2024Bioengineering