Author

E. J. Gandy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Organism:mouse· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. S. Kennedy· 2 shared B. P. Riesenberg· 2 shared E. G. Hunt· 2 shared J. E. Thaxton· 2 shared K. E. Hurst· 2 shared P. Gao· 2 shared A. M. Andrews· 1 shared E. D. Wallace· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersImmunology

A. S. Kennedy

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Acetyl-CoA Carboxylase Obstructs CD8+ T-Cell Lipid Utilization and Energy Synthesis in the Tumor Microenvironment

E. G. Hunt, K. E. Hurst, B. P. Riesenberg, A. S. Kennedy, E. J. Gandy, A. M. Andrews, E. D. Wallace, P. Gao, M. Coleman, J. E. Thaxton

This study shows that acetyl-CoA carboxylase (ACC) activity in T cells within the tumor microenvironment inhibits lipid utilization and energy synthesis, and its restriction enhances T cell survival and antitumor function.

bioRxiv · Nov 16, 2023 · PreprintImmunology

Adaptive IRE1 Signaling Elicits T Cell Metabolic Remodeling and Tumor Control

B. P. Riesenberg, E. J. Gandy, A. S. Kennedy, E. G. Hunt, K. E. Hurst, E. L. Sedlacek, P. Gao, M. J. Emanuele, J. Modliszewski, J. M. Green, J. J. Milner, L. Wiseman, J. E. Thaxton

This study shows that enhancing the adaptive IRE1 UPR pathway in T cells improves tumor control by reducing mitochondrial toxicity and chronic ER stress.

bioRxiv · Nov 16, 2023 · PreprintImmunology