Author

E. J. Goldsmith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:Drosophila· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1

Frequent Co-Authors

H. He· 2 shared J. M. Humphreys· 2 shared M. H. Cobb· 2 shared A. B. Jaykumar· 1 shared A. R. Rodan· 1 shared A. Radha· 1 shared C. Wichaidit· 1 shared G. W. Pearson· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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2 shared papersBiophysics

H. He

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Author profile →

3 papers

Recent·Most cited

Water and chloride as allosteric inhibitors in WNK kinase osmosensing

E. J. Goldsmith, L. R. Teixeira, A. Radha, J. M. Humphreys, H. He

This study investigates how water and chloride regulate WNK kinase activity through structural and mutagenesis analyses of WNK1 and WNK3.

bioRxiv · Aug 29, 2023Biophysics

WNK1 Enhances Migration and Invasion in Breast Cancer Models

A. B. Jaykumar, J. Jung, P. Parida, T. T. Dang, M. Grzemska, S. Earnest, C. Wichaidit, E. J. Goldsmith, G. W. Pearson, S. Malladi, M. H. Cobb

This study shows that inhibiting WNK1 reduces migration, invasion, and metastasis in breast cancer models.

bioRxiv · Mar 9, 2021Cancer Biology

A pressure sensing protein kinase

R. Akella, K. Sekulski, J. M. Pleinis, J. Liwocha, J. Jiou, H. He, J. M. Humphreys, J. N. Schellinger, J. Hu, M. H. Cobb, L. Joachimiak, A. R. Rodan, E. J. Goldsmith

This paper identifies WNK3 as a direct hydrostatic pressure sensor, showing pressure-induced dimer-to-monomer transition and activation in D. melanogaster.

bioRxiv · Mar 11, 2019 · PreprintBiophysics