Tetraploidy-linked sensitization to CENP-E inhibition in human cells
K. Yoshizawa, A. Matsura, M. Shimada, S. Ishida-Ishihara, T. Yamamoto, K. Yaguchi, E. Kawamoto, T. Kuroda, K. Matsuo, N. Tamaoki, R. Sakai, M. Mishra, R. Uehara
This study shows that tetraploid cells are more sensitive to CENP-E inhibitors than diploid cells, leading to selective growth suppression through mitotic delay and cohesion fatigue.
Molecular Oncology · Feb 11, 2023Peer-reviewedCell Biology