T. Kuroda

Generation of human-pig chimeric renal organoids using iPSC technology

This study generates human-pig chimeric renal organoids using modified human-mouse chimeric methods, demonstrating successful interspecies kidney development.

Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo

This study identifies an antibody, CV804, that targets the conserved S2 domain of coronaviruses and shows broad cross-reactivity and ADCC activity against SARS-CoV-2 and related viruses.

Tetraploidy-linked sensitization to CENP-E inhibition in human cells

This study shows that tetraploid cells are more sensitive to CENP-E inhibitors than diploid cells, leading to selective growth suppression through mitotic delay and cohesion fatigue.

Diversity and characteristics of pTet family plasmids revealed by genomic epidemiology of Campylobacter jejuni from human patients in Toyama, Japan from 2015 to 2019

This study analyzes pTet family plasmids in Campylobacter jejuni isolates from Japan, revealing their diversity and resistance gene distribution.

Adaptive fitness in APC-mutant cells requires chromosome rearrangements

The paper shows that APC-mutant cells gain adaptive fitness through chromosome rearrangements that restore AURKA activity and counteract mitotic defects.

Toward Health Management of Major Labour Force Generation by Using Infection Control Countermeasures for Haematobium Schistosomiasis -assumed to be related to occupational risk- in the Republic of Malawi

This study evaluates the effectiveness of praziquantel mass drug administration (MDA) and urine reagent strips for controlling haematobium schistosomiasis in Malawi's working-age population, showing significant prevalence reduction and cost-effectiveness.