Author

S. Ishida-Ishihara

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Assay:proteomics· 1

Frequent Co-Authors

K. Yaguchi· 2 shared K. Yoshizawa· 2 shared R. Uehara· 2 shared A. Matsura· 1 shared E. Kawamoto· 1 shared E. Margittai· 1 shared G. Banhegyi· 1 shared G. Yang· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

K. Yaguchi

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2 papers

Recent·Most cited

Fragility of ER homeostatic regulation underlies haploid instability in human somatic cells

S. Ishida-Ishihara, K. Yaguchi, K. Sato, K. Yoshizawa, S. Miura, G. Yang, K. Veszelyi, G. Banhegyi, E. Margittai, R. Uehara

This study identifies ER stress-induced proteotoxicity as a key factor causing haploid instability in human somatic cells, showing that haploids are more prone to apoptosis due to inefficient proteostasis.

bioRxiv · Apr 5, 2024Biochemistry

Tetraploidy-linked sensitization to CENP-E inhibition in human cells

K. Yoshizawa, A. Matsura, M. Shimada, S. Ishida-Ishihara, T. Yamamoto, K. Yaguchi, E. Kawamoto, T. Kuroda, K. Matsuo, N. Tamaoki, R. Sakai, M. Mishra, R. Uehara

This study shows that tetraploid cells are more sensitive to CENP-E inhibitors than diploid cells, leading to selective growth suppression through mitotic delay and cohesion fatigue.

Molecular Oncology · Feb 11, 2023Peer-reviewedCell Biology