K. Yaguchi

Fragility of ER homeostatic regulation underlies haploid instability in human somatic cells

This study identifies ER stress-induced proteotoxicity as a key factor causing haploid instability in human somatic cells, showing that haploids are more prone to apoptosis due to inefficient proteostasis.

Multivalent coiled-coil interactions enable full-scale centrosome assembly and strength

The paper identifies coiled-coil interactions in SPD-5 that enable centrosome assembly and strength by resisting microtubule-mediated forces.

Tetraploidy-linked sensitization to CENP-E inhibition in human cells

This study shows that tetraploid cells are more sensitive to CENP-E inhibitors than diploid cells, leading to selective growth suppression through mitotic delay and cohesion fatigue.

Mevalonate pathway-mediated ER homeostasis is required for haploid stability in human somatic cells

This study shows that the mevalonate pathway regulates ER homeostasis, which is essential for maintaining haploid stability in human somatic cells.

Uncoupling of DNA replication and centrosome duplication cycles is a primary cause of haploid instability in mammalian somatic cells

This study shows that uncoupling DNA replication and centrosome duplication causes haploid instability in mammalian cells and demonstrates a method to restore coupling and improve stability.

Uncoordinated centrosome duplication cycle underlies the instability of non-diploid states in mammalian somatic cells

The paper shows that centrosome duplication cycle incompatibility with DNA replication causes instability in non-diploid mammalian somatic cells.