Author

E. L. Morgan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Research Focus:cancer & tumor microenvironment· 4 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Macdonald· 4 shared M. R. Patterson· 3 shared A. Samson· 2 shared C. W. Wasson· 2 shared D. Barba-Moreno· 2 shared D. Evans· 2 shared J. A. Scarth· 2 shared A. A. Macdonald· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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4 shared papersCancer Biology

A. Macdonald

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

E7-mediated repression of miR-203 promotes LASP1-dependent proliferation in HPV-positive cervical cancer

M. R. Patterson, A. S. Meijers, E. L. Ryder, J. A. Scarth, D. Evans, A. L. Turner, C. W. Wasson, J. E. Darell, C. D. James, M. Wang, J. E. Ladbury, I. M. Morgan, A. Samson, E. L. Morgan, A. Macdonald

This study shows that HPV E7 represses miR-203, leading to LASP1 upregulation and promoting proliferation in HPV-positive cervical cancer.

bioRxiv · Jan 8, 2024Cancer Biology

The virus-encoded ion channel "viroporin" activity of the agnoprotein is required for BK Polyomavirus release from infected kidney cells

G. Swinscoe, E. L. Prescott, D. L. Hurdiss, E. L. Morgan, S. J. Dobson, T. A. Edwards, R. Foster, M. Welberry-Smith, A. A. Macdonald

This study identifies agnoprotein as a viroporin required for BK polyomavirus release from infected cells and identifies small molecules that inhibit its activity.

bioRxiv · Jan 30, 2023 · PreprintMicrobiology

Exploitation of ATP-sensitive potassium ion (KATP) channels by HPV promotes cervical cancer cell proliferation by contributing to MAPK/AP-1 signalling

J. A. Scarth, C. W. Wasson, M. R. Patterson, D. Evans, D. Barba-Moreno, H. Carden, A. Whitehouse, J. Mankouri, A. Samson, E. L. Morgan, A. Macdonald

This study shows that HPV exploits KATP channels to promote cervical cancer cell proliferation through MAPK/AP-1 signaling.

bioRxiv · Sep 22, 2022Microbiology

The deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancer

E. L. Morgan, M. R. Patterson, D. Barba-Moreno, A. Wilson, A. Macdonald

This study identifies USP13 as an oncogene in cervical cancer that stabilizes Mcl-1, enhancing cell survival and sensitivity to ABT-263.

bioRxiv · Jul 25, 2020Microbiology

Autocrine STAT3 activation in HPV positive cervical cancer through a virus-driven Akt - NF?B - IL-6 signalling axis

E. L. Morgan, A. Macdonald

This study identifies an IL-6-driven STAT3 activation pathway in HPV-positive cervical cancer cells, mediated by Akt and NF-κB, suggesting therapeutic targets.

bioRxiv · Dec 29, 2018Cancer Biology